Antibacterial agent 348 

Antibacterial agent 348 is an antimicrobial agent containing piperazine-isopropanolamine bifunctional groups. Antibacterial agent 348 suppresses virulence factor expression in plant pathogens. Antibacterial agent 348 compromises bacterial membrane integrity, leading to cytoplasmic leakage. Antibacterial agent 348 inhibits cellular proliferation of plant pathogens, diminishes colonization and infectivity of plant pathogens in host plants. Antibacterial agent 348 can be used for the research of rice bacterial leaf blight, pepper phytophthora blight^[1].

Antibacterial agent 348 (Compound Q17) potently inhibits Phytophthora capsica (p.c.) mycelial growth with an EC₅₀ of 9.8 μg/mL^[1].
Antibacterial agent 348 potently inhibits Xanthomonas oryzae pv oryzae (Xoo) growth with an EC₅₀ of 0.9 μg/mL, achieving complete inhibition at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) potently inhibits Xanthomonas axonopodis pv citri (Xac) growth with an EC₅₀ of 11.9 μg/mL, achieving 98.3% inhibition at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) inhibits Xanthomonas campestris pv Mangifera indica (Xcm) growth by 75.1% at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) inhibits Acidovorax citrulli (Ac) growth by 79.0% at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) potently inhibits Sclerotinia sclerotiorum (S.s) mycelial growth at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) inhibits Botryosphaeria dothidea (B.d) mycelial growth by 82.6-84.5% at 100 μg/mL^[1].
Antibacterial agent 348 (100 μg/mL) inhibits Fusarium graminearum (F.g) mycelial growth by 89.2% at 100 μg/mL^[1].
Antibacterial agent 348 (25-50 μg/mL) causes concentration-dependent morphological damage to P.c mycelium, with severe shrinkage and growth inhibition observed at 50 μg/mL^[1].
Antibacterial agent 348 (50 μg/mL) disrupts the structural integrity of Xoo cells at 50 μg/mL, causing cell rupture and membrane collapse^[1].
Antibacterial agent 348 (12.5-100 μg/mL) induces concentration-dependent cytoplasmic leakage in P.c mycelium, damaging cell membrane integrity^[1].
Antibacterial agent 348 (6.25-50 μg/mL) inhibits P.c mycelial growth in a concentration-dependent manner, reducing mycelial biomass at concentrations as low as 6.25 μg/mL^[1].
Antibacterial agent 348 (0.39-25 μg/mL) inhibits Xoo growth in a concentration-dependent manner, nearly halting growth at concentrations ≥12.5 μg/mL^[1].
Antibacterial agent 348 (25-100 μg/mL) reduces Xoo extracellular polysaccharide production in a concentration-dependent manner, with near-complete suppression at 100 μg/mL^[1].
Antibacterial agent 348 (50-200 μg/mL) suppresses Xoo extracellular cellulase and amylase activities in a concentration-dependent manner, with maximum inhibition at 200 μg/mL^[1].
Antibacterial agent 348 (0.39-25 μg/mL) disrupts Xoo biofilm formation in a concentration-dependent manner, achieving 97.1% inhibition at 12.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

559.67

C₃₃H₃₈FN₃O₄

O=C1C(OCCCN2CCN(CC(O)CNCC3=CC=C(F)C=C3)CC2)=C(C4=CC=C(C)C=C4)OC5=C1C=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qiu Y, et al. Design, Synthesis, and Biological Activity Studies of Flavonol Derivatives Containing Isopropanolamine and Piperazine. J Agric Food Chem. 2026;74(20):15426-15436.