Diorcinol D
Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candida albicans. Diorcinol D is applicable to research related to fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 1464778-45-7
- Formula: C19H22O3
- Molecular Weight:298.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Diorcinol D inhibits planktonic growth of wild-type, Fluconazole (HY-B0101)-sensitive, Fluconazole-resistant and efflux pump-mutant Candida albicans strains, with an MIC range of 6 μg/mL to 16 μg/mL. Notably, the CDR1-deficient mutant shows increased sensitivity (MIC = 6 μg/mL)[1].
Diorcinol D (24 h) inhibits the growth of mature biofilms formed by wild-type, fluconazole-sensitive and fluconazole-resistant Candida albicans strains, with an MIC of 32 μg/mL[1].
Diorcinol D (8-32 μg/mL; 48 h) significantly increases cell death in mature Candida albicans YEM30 biofilms at the concentration of 32 μg/mL[1].
Diorcinol D (4-12 μg/mL; 30 min) dose-dependently inhibits ATP-driven Rh123 efflux in both fluconazole-sensitive Candida albicans strain 18B and fluconazole-resistant strain 28I[1].
Diorcinol D (4-12 μg/mL; 3 h) reduces the expression of CDR1 in Candida albicans CASA1 in a dose-dependent manner[1].
Diorcinol D (4-12 μg/mL; 3 h) dose-dependently reduces ergosterol biosynthesis in Fluconazole-susceptible Candida albicans strain 18B and Fluconazole-resistant strain 28I, with a reduction range of 6.1% to 37.2%[1].
Diorcinol D (8 μg/mL; 3 h) reduces the CYP51 gene expression level by 2.8-fold in Fluconazole-susceptible Candida albicans strain 18B, and by 1.8-fold in Fluconazole-resistant Candida albicans strain 28I[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Candida albicans CASA1
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Concentration:4, 8, and 12 μg/mL
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Incubation Time:3 h
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Result:Significant decreaseD in GFP fluorescence.
Chemical Information
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CAS No. 1464778-45-7
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Molecular Weight 298.38
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Formula C19H22O3
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SMILES
CC1=CC(OC2=CC(O)=CC(C)=C2C/C=C(C)/C)=CC(O)=C1
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Structure Classification
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Initial Source
endophytic fungus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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