2. Anti-infection
  3. Fungal
  4. Diorcinol D

Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candida albicans. Diorcinol D is applicable to research related to fungal infections.

For research use only. We do not sell to patients.

Diorcinol D

Diorcinol D Chemical Structure

CAS No. : 1464778-45-7

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Diorcinol D Related Antibodies

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Description

Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candida albicans. Diorcinol D is applicable to research related to fungal infections[1].

In Vitro

Diorcinol D inhibits planktonic growth of wild-type, Fluconazole (HY-B0101)-sensitive, Fluconazole-resistant and efflux pump-mutant Candida albicans strains, with an MIC range of 6 μg/mL to 16 μg/mL. Notably, the CDR1-deficient mutant shows increased sensitivity (MIC = 6 μg/mL)[1].
Diorcinol D (24 h) inhibits the growth of mature biofilms formed by wild-type, fluconazole-sensitive and fluconazole-resistant Candida albicans strains, with an MIC of 32 μg/mL[1].
Diorcinol D (8-32 μg/mL; 48 h) significantly increases cell death in mature Candida albicans YEM30 biofilms at the concentration of 32 μg/mL[1].
Diorcinol D (4-12 μg/mL; 30 min) dose-dependently inhibits ATP-driven Rh123 efflux in both fluconazole-sensitive Candida albicans strain 18B and fluconazole-resistant strain 28I[1].
Diorcinol D (4-12 μg/mL; 3 h) reduces the expression of CDR1 in Candida albicans CASA1 in a dose-dependent manner[1].
Diorcinol D (4-12 μg/mL; 3 h) dose-dependently reduces ergosterol biosynthesis in Fluconazole-susceptible Candida albicans strain 18B and Fluconazole-resistant strain 28I, with a reduction range of 6.1% to 37.2%[1].
Diorcinol D (8 μg/mL; 3 h) reduces the CYP51 gene expression level by 2.8-fold in Fluconazole-susceptible Candida albicans strain 18B, and by 1.8-fold in Fluconazole-resistant Candida albicans strain 28I[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diorcinol D Related Antibodies

Immunofluorescence[1]

Cell Line: Candida albicans CASA1
Concentration: 4, 8, and 12 μg/mL
Incubation Time: 3 h
Result: Significant decreaseD in GFP fluorescence.
Molecular Weight

298.38

Formula

C19H22O3
CAS No.
SMILES

CC1=CC(OC2=CC(O)=CC(C)=C2C/C=C(C)/C)=CC(O)=C1
Structure Classification
Initial Source

endophytic fungus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Diorcinol D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diorcinol D1464778-45-7FungalCdr1mature biofilmsergosterol biosynthesisplanktonic cellsCandida albicansazole-sensitive isolatesefflux pump activityazole drug resistanceCYP51azole-resistant isolatesInhibitorinhibitorinhibit

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