TP-S1-68 

TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC₅₀ of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections^[1][2].

TP-S1-68 inhibits the activity of purified recombinant human TIE-2 kinase with an IC₅₀ of 3.650 μM, and suppresses 101.62% of the kinase activity at a concentration of 5 μg/mL^[1].
TP-S1-68 (Compound 5a) exhibits antimicrobial activity against the bacteria Staphylococcus aureus (MTCC 3160), Staphylococcus epidermidis (MTCC 435), Bacillus cereus (MTCC 9786), Escherichia coli (MTCC 118), Klebsiella pneumoniae (MTCC 3384), Pseudomonas aeruginosa (MTCC 4673), and the fungi Candida albicans (MTCC 1637) and Aspergillus niger (MTCC 282), with MIC values of 6.25, 6.25, 6.25, 12.5, 12.5, 12.5, 6.25, and 6.25 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

312.78

C₁₅H₉ClN₄S

120187-04-4

ClC=1C=CC(=CC1)C2=NN=C3SC(=NN32)C=4C=CC=CC4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan P, et al. Identification and Preliminary SAR Analysis of Novel Type-I Inhibitors of TIE-2 via Structure-Based Virtual Screening and Biological Evaluation in in vitro Models. J Chem Inf Model. 2015;55(12):2693-2704.  [Content Brief]

  [2]. Jagdish K. Sahu, et al. Synthesis, SAR and Molecular Docking Studies of Certain New Derivatives of 1,2,4-Triazolo [3,4-b][1,3,4] Thiadiazole as Potent Antimicrobial Agents. Anti-Infective Agents, 2018, 16, 40-48.

  [3]. Shawali, A. S.,, et al.. Tandem regioselective 1,5-electrocyclizations of bis-nitrilimines—a new convenient synthesis of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. Journal of Sulfur Chemistry, 27(3), 233–244.