120187-04-4
Chemical Structure
TP-S1-68
- CAS No.: 120187-04-4
- Formula:C15H9ClN4S
- Molecular Weight:312.78
IUPAC Name: 3-(4-chlorophenyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
InChIKey: LLMQBOYKIFBXMZ-UHFFFAOYSA-N
SMILES: ClC=1C=CC(=CC1)C2=NN=C3SC(=NN32)C=4C=CC=CC4
Biological Activity: TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC50 of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections[1][2].
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TP-S1-68 | TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC50 of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections. | |||||||||||||||||||||
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- [1]. Pan P, et al. Identification and Preliminary SAR Analysis of Novel Type-I Inhibitors of TIE-2 via Structure-Based Virtual Screening and Biological Evaluation in in vitro Models. J Chem Inf Model. 2015;55(12):2693-2704. [Content Brief]
- [2]. Jagdish K. Sahu, et al. Synthesis, SAR and Molecular Docking Studies of Certain New Derivatives of 1,2,4-Triazolo [3,4-b][1,3,4] Thiadiazole as Potent Antimicrobial Agents. Anti-Infective Agents, 2018, 16, 40-48.
Keywords
