2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Tie
  5. Tie1 Isoform

Tie1

Tie1 is an endothelial receptor tyrosine kinase required for vascular endothelial integrity and survival during blood vessel formation[1][2]. Mechanistically, Tie1 regulates the angiopoietin-Tie2 signaling pathway, where angiogenic endothelial cells use Tie1 to shape tip-cell behavior by reducing Tie2 surface presentation, while remodeling stalk cells use Tie1 to sustain Tie2 signaling[3]. In inflammatory vascular remodeling, Tie1 controls angiopoietin function and supports Ang1- and Ang2-dependent Tie2 activation, linking Tie1 to vessel leakage and inflammation models[4]. In tumor models, endothelial Tie1 deletion inhibits tumor angiogenesis and growth, and Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis[5][6]. Compared with the related Tie2/TEK receptor, Tie1 acts as an orphan, context-dependent regulator rather than a direct angiopoietin receptor, making Tie1-Tie2 coordination central to experimental study design[3][4]. For applications, Tie1-targeting nanobodies and function-blocking antibodies have inhibited endothelial angiogenesis, tumor cell migration, extravasation, and metastasis in preclinical systems[7][8].

Tie1 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-117733
    Zerumin A
    		Inhibitor
    Zerumin A is an anti-angiogenic agent that acts on multiple molecular targets related to angiogenesis (including kdr/VEGFR2, angpt1, angpt2, tie1, and tie2). Zerumin A specifically inhibits the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by regulating the VEGF-VEGFR and ANGPT-TIE signaling pathways, and dose-dependently inhibits angiogenesis (10-20 μM significantly inhibits zebrafish embryo angiogenesis). Zerumin A can be used in the research of cancer and angiogenesis-related inflammatory diseases. Zerumin A can be naturally extracted from the 95% ethanol extract of the fruits, seeds, and pericarp of Alpinia caerulea (R.Br.) Bentham (a plant of the Alpinia genus in the Zingiberaceae family).