2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157018
    Antifungal agent 82
    		Inhibitor
    Antifungal agent 82 (compound G34) is a antifungal agent. Antifungal agent 82 exhibits excellent in vitro antifungal activity against Valsa mali, with an EC50 of 0.57 μg/mL. Antifungal agent 82 also exhibits excellent in vivo protective effects against V. mali at 40 μg/mL.
    Antifungal agent 82
  • HY-124408
    Mepronil
    		Inhibitor 99.91%
    Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
    Mepronil
  • HY-P1508
    Bactenecin
    		Inhibitor
    Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
    Bactenecin
  • HY-156281
    Antifungal agent 76
    		Inhibitor
    Antifungal agent 76 (compound 23h) exhibits potent activities and a broad antifungal spectrum with low MICs of 0.25-16 μg/mL. Antifungal agent 76 might achieve its rapid fungicidal activity by disrupting the fungal cell membrane.
    Antifungal agent 76
  • HY-P11177
    Cn-AMP1
    		Inhibitor
    Cn-AMP1 is a disulfide-free plant peptide that can be isolated from green coconut water. Cn-AMP1 shows activity against multiple pathogenic bacteria, fungal pathogens and cancer cells. Cn-AMP1 is capable of up-regulating inflammatory-cytokine secretion by monocytes. Cn-AMP1 can be used for research on control bacterial infections and cancers.
    Cn-AMP1
  • HY-W004282R
    Undecanoic acid (Standard)
    		Inhibitor
    Undecanoic acid (Standard) (Undecanoate (Standard)) is the analytical standard of Undecanoic acid (HY-W004282). This product is intended for research and analytical applications. Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid (Standard)
  • HY-152136
    Antituberculosis agent-6
    		Inhibitor
    Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption.
    Antituberculosis agent-6
  • HY-155131
    Y18501
    		Inhibitor
    Y18501 is a oxysterol-binding protein (OSBPI) inhibitor with a similar structure to Oxathiapiprolin. Y18501 shows strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC50 ranging from 0.0005 to 0.0046 μg/mL. Y18501 shows excellent protective and curative activities against P. cubensis. Y18501 in combination with Chlorothalonil (HY-N6625) can significantly promote the inhibition of P. cubensis.
    Y18501
  • HY-W671129
    Frenolicin B
    		Inhibitor
    Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC50 of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits Peroxiredoxin 1 via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria.
    Frenolicin B
  • HY-N9711
    1-Methoxyberberine chloride
    		Inhibitor
    1-Methoxyberberine chloride is a plant alkaloid that can be found in Corydalis longipes. 1-Methoxyberberine chloride exhibits antifungal effects.
    1-Methoxyberberine chloride
  • HY-145407A
    ent-Heronamide C
    		Inhibitor
    ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
    ent-Heronamide C
  • HY-163337
    Antifungal agent 92
    		Inhibitor
    Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III.
    Antifungal agent 92
  • HY-148968
    Metham sodium
    		Inhibitor
    Metham sodium (Carbathion) is a broad-spectrum soil microbial suppressant. Metham sodium controls soil-borne pests and weeds. Metham sodium inhibits weed seeds, plant-parasitic nematodes, plant pathogenic fungi and soil insects.
    Metham sodium
  • HY-124384
    Pseudoanguillosporin A
    		Inhibitor
    Pseudoanguillosporin A (Soudanone A) (Compound 3) is an isochromanone that can be isolated from the fungus Cadophora sp.. Pseudoanguillosporin A has significant antifungal activity against Cryptococcus neoformans with a MIC50 of 40 μg/mL. Pseudoanguillosporin A can be used for fungal infection research.
    Pseudoanguillosporin A
  • HY-D0008
    Brilliant green
    		Inhibitor
    Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria.
    Brilliant green
  • HY-N16053
    Antibacterial agent 288
    		Inhibitor
    Antibacterial agent 288 (Compound 1) has antibacterial and antifungal activities. Antibacterial agent 288 can be isolated from Mangrove fungus (No. B60) from the South China Sea.
    Antibacterial agent 288
  • HY-N7719R
    Oosporein (Standard)
    		Inhibitor
    Oosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity.
    Oosporein (Standard)
  • HY-N12180A
    Hodgkinsine
    		Inhibitor
    Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities.
    Hodgkinsine
  • HY-153618
    Antifungal agent 53
    		Inhibitor
    Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.
    Antifungal agent 53
  • HY-P11141
    Jelleine-II
    		Inhibitor
    Jelleine-II is a short chain antibacterial peptide derived from royal jelly, with broad-spectrum antibacterial activity. Jelleine-II has antibacterial activity against yeast, fungi, Gram positive bacteria, and Gram negative bacteria. Jelleine-II can be used in the study of infectious conditions.
    Jelleine-II
Cat. No. Product Name / Synonyms Application Reactivity