Antifungal agent 53
Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.
For research use only. We do not sell to patients.
- CAS No.: 2422019-76-7
- Formula: C18H15Cl3N2Se
- Molecular Weight:444.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
1.02 μM
Compound: A03
|
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 33713977] |
| MCF-10A | IC50 |
30.16 μM
Compound: A03
|
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 33713977] |
| MDA-MB-231 | IC50 |
9.06 μM
Compound: A03
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 33713977] |
| PC-3 | IC50 |
13.1 μM
Compound: A03
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 33713977] |
Antifungal agent 53 (4 μg/mL; 24 h) displayed less hemolytic effect than Miconazole (HY-B0454), against rabbit red blood cells[1].
Antifungal agent 53 (50 μg/mL, 80 μg/mL; 1.5-24 h) inhibits the formation of C. albicans biofilm in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2422019-76-7
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Molecular Weight 444.64
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Formula C18H15Cl3N2Se
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SMILES
ClC1=CC=C(C([Se]CC2=CC=CC=C2Cl)CN3C=CN=C3)C(Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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