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製品番号: HY-153618

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Antifungal agent 53

Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 2422019-76-7
分子式: C₁₈H₁₅Cl₃N₂Se
分子量:444.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antifungal agent 53 構造式

CAS 番号: 2422019-76-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	1.02 μM Compound: A03	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 33713977]
MCF-10A	IC₅₀	30.16 μM Compound: A03	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 33713977]
MDA-MB-231	IC₅₀	9.06 μM Compound: A03	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 33713977]
PC-3	IC₅₀	13.1 μM Compound: A03	Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 33713977]

体外実験

Antifungal agent 53 (4 μg/mL; 24 h) displayed less hemolytic effect than Miconazole (HY-B0454), against rabbit red blood cells^[1].
Antifungal agent 53 (50 μg/mL, 80 μg/mL; 1.5-24 h) inhibits the formation of C. albicans biofilm in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2422019-76-7
分子量 444.64
分子式 C₁₈H₁₅Cl₃N₂Se
SMILES

ClC1=CC=C(C([Se]CC2=CC=CC=C2Cl)CN3C=CN=C3)C(Cl)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu H, et al. Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. Eur J Med Chem. 2020 Jul 15;198:112360. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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