Bactenecin (Synonyms: Bactenecin, bovine)

Cat. No.: HY-P1508: FAQs
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Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.

For research use only. We do not sell to patients.

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Bactenecin Chemical Structure

CAS No. : 116229-36-8

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Other Forms of Bactenecin:

Bactenecin TFA In-stock

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Description	Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei*^[1]^[2]^[3].
IC₅₀ & Target	Bacteria; Yeast; Fungus^[1]
In Vitro	Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum^[1]. Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells^[2]. Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Bactenecin Related Antibodies
Molecular Weight	1483.89
Formula	C₆₃H₁₁₈N₂₄O₁₃S₂
CAS No.	116229-36-8
Sequence	Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg (Disulfide bridge: Cys3-Cys11)
Sequence Shortening	RLCRIVVIRVCR (Disulfide bridge: Cys3-Cys11)
Structure Classification	Antibiotics Disease Research Antibacterial Antibiotics Other Antibiotics
Initial Source	Animals bovine neutrophils
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [Content Brief] [2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62. [Content Brief] [3]. Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. [Content Brief]

Cell Assay
^[2]

Rat neuronal cells (5000 cells/well) are incubated for 24 hr with bactenecin (0.3, 0.6, 1.25, 2.5, 5, 10, 20, 40 μg/mL) or the control peptide. Cytotoxicity is assayed in 96-well tissue culture plates using a commercially available kit. The method is based on cellular reduction of tetrazolium salt into intensely coloured formazan derivates.^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [Content Brief]

[2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62. [Content Brief]

[3]. Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. [Content Brief]

Bactenecin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bactenecin116229-36-8Bactenecin, bovineBacterialFungalAntibioticAntimicrobialpeptidebacteriayeastdodecapeptideneurotoxicityheterogenouscationicInhibitorinhibitorinhibit

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