1. Anti-infection
  2. Bacterial
    Fungal
  3. Bactenecin TFA

Bactenecin TFA (Synonyms: Bactenecin, bovine TFA)

Cat. No.: HY-P1508A
Handling Instructions

Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bactenecin TFA Chemical Structure

Bactenecin TFA Chemical Structure

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Description

Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei[1][2][3].

IC50 & Target

Bacteria; Yeast; Fungus[1]

In Vitro

Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum[1].
Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells[2]. Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane[3].

Molecular Weight

1597.94

Formula

C₆₅H₁₁₉F₃N₂₄O₁₅S₂

Sequence

Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg (Disulfide bridge: Cys3-Cys11)

Sequence Shortening

RLCRIVVIRVCR (Disulfide bridge: Cys3-Cys11)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BactenecinBactenecin, bovineBacterialFungalAntimicrobialpeptidebacteriayeastdodecapeptideneurotoxicityheterogenouscationicInhibitorinhibitorinhibit

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Bactenecin TFA
Cat. No.:
HY-P1508A
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