2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N20641
    Turonicin A
    		Inhibitor
    Turonicin A is an anti-fungal and anti-bacterial agent found in Australian Streptomyces sp. MST-123921. Turonicin A inhibits growth of Candida albicans and Saccharomyces cerevisiae fungi. Turonicin A inhibits growth of Bacillus subtilis and Staphylococcus aureus bacteria. Turonicin A can be used for the research of fungal infections, bacterial infections.
    Turonicin A
  • HY-N6739R
    Beauvericin (Standard)
    		Inhibitor
    Doxycycline (monohydrate) (Standard) is the analytical standard of Doxycycline (monohydrate). This product is intended for research and analytical applications. Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.
    Beauvericin (Standard)
  • HY-P11342
    Verlamelin A
    		Inhibitor
    Verlamelin A is a macrocyclic depsipeptide with antifungal and antiviral activity. Verlamelin A shows antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also has antiviral activity toward HSV-1 (IC50 = 16.7 μM). Verlamelin A is isolated from the entomopathogenic fungus Lecanicillium sp. Verlamelin A is useful for antifungal and antiviral research.
    Verlamelin A
  • HY-N11772R
    Mutanocyclin (Standard)
    		Inhibitor
    Taurodeoxycholate (sodium salt) (Standard) is the analytical standard of Taurodeoxycholate (sodium salt). This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses .
    Mutanocyclin (Standard)
  • HY-U00007
    Stilbamidine
    		Inhibitor
    Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
    Stilbamidine
  • HY-114335
    Triphala
    		Inhibitor
    Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
    Triphala
  • HY-N2229R
    Rhapontigenin (Standard)
    		Inhibitor
    Rhapontigenin (Standard) is the analytical standard of Rhapontigenin. This product is intended for research and analytical applications. Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.
    Rhapontigenin (Standard)
  • HY-152138
    Antituberculosis agent-8
    		Inhibitor
    Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM.
    Antituberculosis agent-8
  • HY-N15755
    Sepiumol A
    		Inhibitor
    Sepiumol A is a polyphenolic compound that can be isolated from the bark of Periploca sepium Bunge. Sepiumol A has antibacterial and antifungal activities. Sepiumol A can be added to e-cigarette liquid to exert antibacterial effects and reduce the sweetness and greasiness during smoking.
    Sepiumol A
  • HY-B1324A
    Oxiconazole
    		Inhibitor
    Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
    Oxiconazole
  • HY-B2048
    Pencycuron
    		Inhibitor
    Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight.
    Pencycuron
  • HY-178177
    SDH-IN-31
    		Inhibitor
    SDH-IN-31 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.11 μM. SDH-IN-31 exhibits anti-fungal activity. SDH-IN-31 can be used for the research of infection, such as infection, such as rice sheath blight.
    SDH-IN-31
  • HY-129291
    Reductiomycin
    		Inhibitor
    Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity.
    Reductiomycin
  • HY-172777
    SDH-IN-25
    		Inhibitor
    SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.
    SDH-IN-25
  • HY-147999
    GlcN-6-P Synthase-IN-1
    		Inhibitor
    GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform.
    GlcN-6-P Synthase-IN-1
  • HY-N8507
    Tunicamycin B
    		Inhibitor
    Tunicamycin B is a Tunicamycin (HY-A0098) derivative with antimicrobial activity. Tunicamycin B shows antibacterial activity against Bacillus thuringiensis BT01 and B. thuringiensis W102 (MICs of 0.125 and 0.063 μg/mL, respectively) and antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 (MICs of 8.0 and 4.0 μg/mL, respectively). Tunicamycin B can be used for antimicrobial research.
    Tunicamycin B
  • HY-137989S
    Voriconazole N-oxide-d3
    		Inhibitor
    Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).
    Voriconazole N-oxide-d<sub>3</sub>
  • HY-W743904
    Quininone
    		Inhibitor
    Quininone is a Quinine (HY-D0143) derivative that exhibits in vitro antifungal activity. Quininone can be used for antifungal research.
    Quininone
  • HY-N4145
    Procyanidin A3
    		Inhibitor
    Procyanidin A3 (Cinnamtannin A3; Cinnamtannin II) is a sub class of Proanthocyanidins (HY-N0794). Proanthocyanidin are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancer agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy.
    Procyanidin A3
  • HY-P1940R
    Maculosin (Standard)
    		Inhibitor
    Complanatuside (Standard) is the analytical standard of Complanatuside. This product is intended for research and analytical applications. Complanatuside is a flavonoid found in the traditional Chinese medicine Semen Astragali Complanati.
    Maculosin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity