SDH-IN-25
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.
For research use only. We do not sell to patients.
- CAS No.: 3052432-15-9
- Formula: C19H15BrCl2N2O4
- Molecular Weight:486.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SDH-IN-25 (Compound 7IIj) (0-20 mg/L) demonstrates excellent and broad-spectrum fungicidal effects against 8 phytopathogenic strains including R. solani (EC50 = 0.179 mg/L), P. piricola (EC50 = 0.301 mg/L), S. sclerotiorum (EC50 = 3.47 mg/L), V. mali (EC50 = 0.789 mg/L), F. graminearum (EC50 = 6.29 mg/L), B. cinerea (EC50 = 0.647 mg/L), P. capsici (EC50 = 5.78 mg/L), and G. graminis (EC50 = 0.549 mg/L)[1].
SDH-IN-25 (5-20 mg/L, 1-9 h) results in the inhibition of respiratory metabolism of R. solani[1].
SDH-IN-25 (0-20 mg/L, 2 d) exhibits excellent R. solani SDH inhibitory activity with an IC50 value of 4.82 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SDH-IN-25 (100 mg/L, 10 min) shows a significant preventive effect on detached rice leaves with R. solani (control efficacy of 88.7%) and on rice plants with R. solani (control efficacy of 69.8%), where safety for rice is verified[1].
SDH-IN-25 (1 mg/L, 72 h) results in abnormal mycelial growth, characterized by desiccated, collapsed, and shriveled surfaces of R. solani hyphae[1].
SDH-IN-25 (0.179 mg/L) leads to increased ROS level and disruption of MMP in hyphae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3052432-15-9
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Molecular Weight 486.14
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Formula C19H15BrCl2N2O4
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SMILES
ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-25 Related Classifications
HY-172777 Related Classifications
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