3052432-15-9
Chemical Structure
SDH-IN-25
- CAS No.: 3052432-15-9
- Formula:C19H15BrCl2N2O4
- Molecular Weight:486.14
SMILES: ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1
Biological Activity: SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control[1].
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SDH-IN-25 | SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control. | |||||||||||||||||||||
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