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Cat. No.: HY-N20641

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Turonicin A

Turonicin A is an anti-fungal and anti-bacterial agent found in Australian Streptomyces sp. MST-123921. Turonicin A inhibits growth of Candida albicans and Saccharomyces cerevisiae fungi. Turonicin A inhibits growth of Bacillus subtilis and Staphylococcus aureus bacteria. Turonicin A can be used for the research of fungal infections, bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 3059457-35-8
Formula: C₆₃H₉₉N₃O₁₅
Molecular Weight:1138.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Turonicin A Chemical Structure

CAS No.: 3059457-35-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Turonicin A (48 h) exhibits moderate antibacterial activity against Bacillus subtilis (MIC 0.097 μg/mL, 85 nM) and Staphylococcus aureus (MIC 0.39 μg/mL, 340 nM)^[1].
Turonicin A (48 h) exhibits very potent antifungal activity against Candida albicans (MIC 0.0031 μg/mL, 2.7 nM) and Saccharomyces cerevisiae (MIC 0.0008 μg/mL, 0.7 nM)^[1].
Turonicin A (96 h) exhibits low cytotoxicity against NS-1 murine myeloma cells (IC₅₀ 44 μM) and no cytotoxicity against NFF neonatal foreskin fibroblasts up to >80 μM^[1].
Turonicin A (72 h) shows no herbicidal activity against Eragrostis tef seed germination up to >100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2
Cynomolgus Monkey^[2]	20 mg/kg	i.v.	110.4 h
Cynomolgus Monkey^[2]	60 mg/kg	i.v.	115.2 h
Cynomolgus Monkey^[2]	120 mg/kg	i.v.	129.6 h

Chemical Information

CAS No. 3059457-35-8
Molecular Weight 1138.47
Formula C₆₃H₉₉N₃O₁₅
SMILES

OC(/C(C)=C/C=C/C=C/C=C/CC/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@H](O)/C=C/C=C/C=C/C=C/C=C/C[C@H](O)[C@H](C)C(C[C@@H](C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCNC(N)=N)O)=O)=O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen R, et al. Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp. J Nat Prod. 2023 Aug 25;86(8):2054-2058. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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