1. Anti-infection
  2. Fungal Bacterial
  3. Turonicin A

Turonicin A is an anti-fungal and anti-bacterial agent found in Australian Streptomyces sp. MST-123921. Turonicin A inhibits growth of Candida albicans and Saccharomyces cerevisiae fungi. Turonicin A inhibits growth of Bacillus subtilis and Staphylococcus aureus bacteria. Turonicin A can be used for the research of fungal infections, bacterial infections.

For research use only. We do not sell to patients.

Turonicin A

Turonicin A Chemical Structure

CAS No. : 3059457-35-8

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Description

Turonicin A is an anti-fungal and anti-bacterial agent found in Australian Streptomyces sp. MST-123921. Turonicin A inhibits growth of Candida albicans and Saccharomyces cerevisiae fungi. Turonicin A inhibits growth of Bacillus subtilis and Staphylococcus aureus bacteria. Turonicin A can be used for the research of fungal infections, bacterial infections[1].

In Vitro

Turonicin A (48 h) exhibits moderate antibacterial activity against Bacillus subtilis (MIC 0.097 μg/mL, 85 nM) and Staphylococcus aureus (MIC 0.39 μg/mL, 340 nM)[1].
Turonicin A (48 h) exhibits very potent antifungal activity against Candida albicans (MIC 0.0031 μg/mL, 2.7 nM) and Saccharomyces cerevisiae (MIC 0.0008 μg/mL, 0.7 nM)[1].
Turonicin A (96 h) exhibits low cytotoxicity against NS-1 murine myeloma cells (IC50 44 μM) and no cytotoxicity against NFF neonatal foreskin fibroblasts up to >80 μM[1].
Turonicin A (72 h) shows no herbicidal activity against Eragrostis tef seed germination up to >100 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics
Species Dose Route T1/2
Cynomolgus Monkey[2] 20 mg/kg i.v. 110.4 h
Cynomolgus Monkey[2] 60 mg/kg i.v. 115.2 h
Cynomolgus Monkey[2] 120 mg/kg i.v. 129.6 h
Molecular Weight

1138.47

Formula

C63H99N3O15

CAS No.
SMILES

OC(/C(C)=C/C=C/C=C/C=C/CC/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@H](O)/C=C/C=C/C=C/C=C/C=C/C[C@H](O)[C@H](C)C(C[C@@H](C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCNC(N)=N)O)=O)=O

Structure Classification
Initial Source

Streptomyces sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Turonicin A
Cat. No.:
HY-N20641
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