1. Anti-infection Metabolic Enzyme/Protease
  2. Fungal Cytochrome P450 Antibiotic
  3. Oxiconazole

Oxiconazole  (Synonyms: Ro 13-8996 free base)

Cat. No.: HY-B1324A
Handling Instructions

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.

For research use only. We do not sell to patients.

Oxiconazole Chemical Structure

Oxiconazole Chemical Structure

CAS No. : 64211-45-6

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Description

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3].

IC50 & Target[2]

CYP3A4

 

In Vitro

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].
Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1].
Antifungal Activities of Oxiconazole[1].

Candida
albicans
Candida
glabrata
Candida
parapsilosis
Aspergillus
fumigatus
Aspergillus
flavus
Trichophyton
mentagrophytes
Trichophyton
rubrum
Oxiconazole 0.03 μg/mL 0.01 μg/mL 0.008 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration: 0-40 μM
Incubation Time: 24 h
Result: Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.
In Vivo

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)[3]
Dosage: 50 mg/kg/day
Administration: IP; for 12 days
Result: Significantly restrained CRC cell growth and showed no obvious side effects.
Clinical Trial
Molecular Weight

429.13

Formula

C18H13Cl4N3O

CAS No.
SMILES

ClC1=CC=C(/C(CN2C=CN=C2)=N/OCC3=CC=C(Cl)C=C3Cl)C(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Oxiconazole
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HY-B1324A
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