2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W715370
    Pyrametostrobin
    		Inhibitor
    Pyrametostrobin is a strobilurin fungicide used to protect crops from fungal infection. Pyrametostrobin can be applied to research related to cucumber powdery mildew, powdery mildew, rust, downy mildew and blight.
    Pyrametostrobin
  • HY-N19907
    Phomopsinone A
    		Inhibitor
    Phomopsinone A is an Antifungal agent. Phomopsinone A is isolated from Phomopsis sp. Phomopsinone A exhibits activity against plant and crop pathogens Pyricularia oryzae, Septoria tritici and Botrytis cinerea. Phomopsinone A can be used in the research of plant/crop fungal diseases.
    Phomopsinone A
  • HY-N14923
    Nikkomycin Lz
    		Inhibitor
    Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candida albicans.
    Nikkomycin Lz
  • HY-W094881
    1,5-Dimethylnaphthalene
    1,5-Dimethylnaphthalene is a volatile organic compound. 1,5-Dimethylnaphthalene is a good marker for B. cinerea quantification. 1,5-dimethylnaphthalene is highly positively correlated to B. cinerea infection levels in Chardonnay berries.
    1,5-Dimethylnaphthalene
  • HY-W741041
    Fluoxastrobin-d4
    		Inhibitor
    Fluoxastrobin-d4 is the deuterium labeled Fluoxastrobin. Fluoxastrobin is a fungicide agent.
    Fluoxastrobin-d<sub>4</sub>
  • HY-N7063S1
    Nerol-d6
    		Inhibitor
    Nerol-d6 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.
    Nerol-d<sub>6</sub>
  • HY-N14807
    Neobulgarone A
    		Inhibitor
    Neobulgarone A is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone A can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone A
  • HY-155999
    MoTPS1-IN-1
    		Inhibitor 99.50%
    MoTPS1-IN-1 (Compound j11), an antifungal agent, is a MoTPS1 inhibitor. MoTPS1-IN-1 acts by interation with Glu396 in MoTPS1. MoTPS1-IN-1 inhibits pathogenicity of M. oryzae.
    MoTPS1-IN-1
  • HY-N13929
    Scytalidin
    		Inhibitor
    Scytalidin is a terpenoid antibiotic with antifungal effect.
    Scytalidin
  • HY-N14437
    Pradimicin T2
    		Inhibitor
    Pradimicin T2 is an antibiotic. Pradimicin T2 has activity against filamentous fungi and yeast-like fungi.
    Pradimicin T2
  • HY-122955
    Xanthobaccin A
    		Inhibitor
    Xanthobaccin A is a potent antibiotic that can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A exhibits activity against fungi and G+ bacteria, induces zoospore immobilization and lysis, inhibits mycelial growth. Xanthobaccin A can be used for the research of beet damping-off disease, bacterial and fungal infection.
    Xanthobaccin A
  • HY-182276
    Anticandidal agent-2
    		Inhibitor
    Anticandidal agent-2 is an anti-Candida albicans agent with a MIC of 1.6 μg/mL. Anticandidal agent-2 disrupts Candida albicans biofilms and inhibits Candida albicans. Anticandidal agent-2 can be used in the research of Candida albicans infections.
    Anticandidal agent-2
  • HY-168446
    PKR-IN-1
    		Inhibitor
    PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor that has antifungal activity, with an EC50 of 0.21 μg/mL for R. solani.
    PKR-IN-1
  • HY-173428
    Antifungal agent 130
    		Inhibitor
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections.
    Antifungal agent 130
  • HY-N14826
    Nanaomycin E
    		Inhibitor
    Nanaomycin E is an antibiotic. Nanaomycin E has activity against Gram-positive bacteria and fungi.
    Nanaomycin E
  • HY-N13916
    Alternaric acid
    Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca2+ and Mg2+, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2.
    Alternaric acid
  • HY-N19846
    Pithecolobine
    		Inhibitor
    Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts.
    Pithecolobine
  • HY-N14808
    Neobulgarone B
    		Inhibitor
    Neobulgarone B is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone B can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone B
  • HY-B0364AR
    Dyclonine hydrochloride (Standard)
    		Inhibitor
    Dyclonine (hydrochloride) (Standard) is the analytical standard of Dyclonine (hydrochloride). This product is intended for research and analytical applications. Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
    Dyclonine hydrochloride (Standard)
  • HY-N7236
    Pervicoside B
    		Inhibitor
    Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases.
    Pervicoside B
Cat. No. Product Name / Synonyms Application Reactivity