Xanthobaccin A
Xanthobaccin A is a potent antibiotic that can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A exhibits activity against fungi and G+ bacteria, induces zoospore immobilization and lysis, inhibits mycelial growth. Xanthobaccin A can be used for the research of beet damping-off disease, bacterial and fungal infection.
For research use only. We do not sell to patients.
- CAS No.: 227596-81-8
- Formula: C29H38N2O6
- Molecular Weight:510.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Xanthobaccin A (0.001-10 μg/mL; 1-4 h) potently inhibits motility and induces lysis of Aphanomyces cochlioides zoospores in a dose- and time-dependent manner, with an MIC of 0.01 μg/mL[1].
Xanthobaccin A inhibits mycelial growth and induces abnormal morphological changes in Aphanomyces cochlioides hyphae[1].
Xanthobaccin A (0.1 μg/mL; 30 min) induces structural damage and lysis of Aphanomyces cochlioides zoospores within 30 min[1].
Xanthobaccin A (20 μg per disk; 2-7 days) potently inhibits the growth of multiple plant pathogenic fungi (Phytophthora vignae f. sp. adzukicola, Gaeumannomyces graminis var. tritici, Aphanomyces cochlioides and Pythium ultimum)[2].
Xanthobaccin A (1 μg/mL) inhibits the growth of Pythium ultimum with a MIC of 1 μg/mL[3].
Xanthobaccin A (20 µg; 24 h) inhibits the growth of Bacillus subtilis with an MIC of 10 μg/mL[4].
Xanthobaccin A acts as a ferric iron (Fe3+) metallophore, capable of chelating ferric iron ions[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 227596-81-8
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Molecular Weight 510.62
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Formula C29H38N2O6
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SMILES
O=C1[C@@]2([H])[C@@]([C@H]3C)([H])[C@](C[C@@H]3CC)([H])C[C@]2([H])[C@](C/C=C\C(NCC[C@H]4O)=O)([H])[C@@](/C=C/C(C(C5=O)=C([C@@]4([H])N5)O)=O)([H])C1
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Structure Classification
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Initial Source
Stenotrophomonas sp. Strain SB-K88
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Purity & Documentation
References
[1]. Islam MT, et al. Suppression of damping-off disease in host plants by the rhizoplane bacterium Lysobacter sp. strain SB-K88 is linked to plant colonization and antibiosis against soilborne Peronosporomycetes. Appl Environ Microbiol. 2005;71(7):3786-3796. [Content Brief]
[2]. Nakayama T, et al. Possible role of xanthobaccins produced by Stenotrophomonas sp. strain SB-K88 in suppression of sugar beet damping-off disease. Appl Environ Microbiol. 1999;65(10):4334-4339. [Content Brief]
[3]. Nakayama T, et al. Possible role of xanthobaccins produced by Stenotrophomonas sp. strain SB-K88 in suppression of sugar beet damping-off disease. Appl Environ Microbiol. 1999 Oct;65(10):4334-9. [Content Brief]
[4]. Ding L, et al. Polycyclic Tetramate Macrolactams-A Group of Natural Bioactive Metallophores. Front Chem. 2021;9:772858. Published 2021 Nov 12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthobaccin A Related Classifications
HY-122955 Related Classifications
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Keywords
- Xanthobaccin A
- 227596-81-8
- Antibiotic
- Fungal
- Bacterial
- Gaeumannomyces graminis var. tritici
- Streptomyces scabies
- Pyrenochaeta lycopersici
- Bacillus subtilis
- ferric iron
- Stenotrophomonas sp. strain SB-K88
- Pythium ultimum
- Phytophthora vignae f. sp. adzukicola
- Aphanomyces cochlioides
- Actinoalloteichus hymeniacidonis
- Inhibitor
- inhibitor
- inhibit