2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bacterial Fungal Reactive Oxygen Species (ROS)
  4. Pithecolobine

Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts.

For research use only. We do not sell to patients.

Pithecolobine

Pithecolobine Chemical Structure

CAS No. : 22368-82-7

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Pithecolobine Related Antibodies

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Description

Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts[1][2].

In Vitro

Pithecolobine (0.25 mg/disc) exhibits concentration-dependent antimicrobial activity against Escherichia coli NCIM 2065, Klebsiella pneumoniae NCIM 2957, Proteus vulgaris NCIM 2027, Pseudomonas aeruginosa NCIM 5031, Salmonella typhi NCIM 2051, Staphylococcus aureus NCIM 2079, Streptococcus faecalis NCIM 5025, Candida albicans NCIM 3471, and Cryptococcus neoformans NCIM 3541[2].
Pithecolobine (0.95-1000 μg/mL; 24-48 h) inhibits and kills Escherichia coli NCIM 2065, Klebsiella pneumoniae NCIM 2957, Proteus vulgaris NCIM 2027, Pseudomonas aeruginosa NCIM 5031, Salmonella typhi NCIM 2051, Staphylococcus aureus NCIM 2079, Streptococcus faecalis NCIM 5025, Candida albicans NCIM 3471, and Cryptococcus neoformans NCIM 3541[2].
Pithecolobine (31-1000 μg/mL; 30 min) scavenges DPPH radicals with an IC50 of 250 μg/mL in a cell-free in vitro assay[2].
Pithecolobine (1000 μg/mL; 2 h) inhibits β-Carotene (HY-N0411)/Linoleic acid (HY-N0729) bleaching by 70.4% at a concentration of 1000 μg/mL in a cell-free in vitro assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pithecolobine Related Antibodies
Molecular Weight

398.63

Formula

C22H46N4O2
CAS No.
SMILES

O=C1NCCCN(CCCCNCCCNC(CCCCCCC)CCC1)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pithecolobine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pithecolobine22368-82-7BacterialFungalReactive Oxygen Species (ROS)Samanea samanDPPH radicalsEscherichia coli NCIM 2065Gram-negative bacteriaStaphylococcus aureus NCIM 2079human pathogenic bacteriaGram-positive bacteriaKlebsiella pneumoniae NCIM 2957Candida albicans NCIM 3471human pathogenic yeastsInhibitorinhibitorinhibit

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