GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (778)
Related Products (778)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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Kojic amine
0 ImagesCat. No.: HY-121554CAS No.: 68642-64-8Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]-
α,β-Thujone
0 ImagesCat. No.: HY-W751152CAS No.: 76231-76-0α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses.
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HIE-124
0 ImagesCat. No.: HY-129451CAS No.: 805326-00-5HIE-124 is a potent ultra-short acting hypnotic that exhibits a rapid onset of action and a shorter duration of action with no acute tolerance or noticeable side effects. HIE-124 is promising for research of preanesthetic medication and anesthesia inducer.
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Baclofen (Standard)
0 ImagesBaclofen (Standard) is the analytical standard of Baclofen. This product is intended for research and analytical applications. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
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GABA receptor antagonist 3
0 ImagesCat. No.: HY-184987CAS No.: 3106082-79-2GABA receptor antagonist 3 is a GABA receptor antagonist with insecticidal activity. GABA receptor antagonist 3 binds deeply inside the receptor pore, forms stable interactions with key residues to disrupt channel gating, and inhibits GABA-induced currents. GABA receptor antagonist 3 exhibits insecticidal activity against Spodoptera frugiperda. GABA receptor antagonist 3 can be used in pest control research.
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LAU159
0 ImagesCat. No.: HY-112426CAS No.: 2055050-87-6LAU159 is a functionally selective positive modulator of α1β3 GABA(A) receptor with an EC50 of 2.2 μM.
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Terbequinil
0 ImagesCat. No.: HY-105518CAS No.: 113079-82-6Synonyms: SR-25776Terbequinil (SR-25776) is a potent orally active Gamma-aminobutyric acid A (GABAA) receptor inverse agonist. Terbequinil can be used for research on nervous system diseases.
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Leporin A
0 ImagesCat. No.: HY-N16421CAS No.: 140381-54-0Leporin A is an insecticide. Leporin A binds to GABA receptors or sodium channels to disrupt neurotransmission.
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AHN 070
0 ImagesCat. No.: HY-118096CAS No.: 109960-13-6AHN 070 is an irreversible peripheral benzodiazepine receptor (PBR) ligand. AHN 070 can bind to PBR with nanomolar affinity and is pH-dependent. AHN 070 can be used for studying the structure and function of PBR.
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Gidazepam-d5
0 ImagesCat. No.: HY-U00315SSynonyms: Gidasepam-d5; Hidazepam-d5; Hydazepam-d5Gidazepam-d5 is a deuterium labeled Gidazepam. Gidazepam is an agonist of GABA receptor channels (GABA RCs), and has anticonvulsant effect.
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Aminochalcone 4AAF
0 ImagesCat. No.: HY-175263CAS No.: 38239-51-9Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures.
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ZK 93426 hydrochloride
0 ImagesCat. No.: HY-103499CAS No.: 1216792-30-1ZK 93426 (hydrochloride) is a benzodiazepine antagonist. ZK 93426 (hydrochloride) can be used for the research of neurological disease.
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CGP55845
0 ImagesCat. No.: HY-114076CAS No.: 150175-54-5CGP55845 is a potent and selective GABAB receptor antagonist with activity that blocks agonist binding. The IC50 value of CGP55845 is 5 nM, indicating that it exhibits significant activity in inhibiting GABA and glutamate release. The apparent Kd of CGP55845 when forming a complex with the GABAB receptor is 30 nM, indicating its high affinity for this receptor. CGP55845 is as potent as 100 μM CGP 35348 in relieving the inhibitory effect of (R)-(-)-baclofen.
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Org 20599 methanesulfonate
0 ImagesCat. No.: HY-103498ACAS No.: 187652-71-7Org20599 methanesulfonate is a direct agonist of the GABAA receptor with an EC50 of 1.1 μM. Org20599 methanesulfonate can be used in the research of neurological disorders.
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Uldazepam
0 ImagesCat. No.: HY-100264CAS No.: 28546-58-9Synonyms: U31920Uldazepam is a benzodiazepine derivative and has the potential for anxiety syndrome treatment.
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AZD 3043
0 ImagesCat. No.: HY-108204CAS No.: 579494-66-9Synonyms: THRX 918661AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA(A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA(A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.
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3α,21-Dihydroxy-5α-pregnan-20-one-d3
0 ImagesCat. No.: HY-123489SCAS No.: 203805-98-5Synonyms: THDOC-d33α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
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Deschloro-Zopiclone
0 ImagesCat. No.: HY-Z1085CAS No.: 1348046-61-6Deschloro-Zopiclone is an impurity of Zopiclone. Zopiclone is the first non-benzodiazepine compound, which can enhance the activity of inhibitory neurotransmitter gamma amino butyric acid in the brain.
