CGP55845

CGP55845 (1 µM) increases spontaneous GABAergic network activity and Ca²⁺ transient frequency by blocking GABA_B receptors in mouse visual cortex Cajal-Retzius cells^[1].
CGP55845 (1 µM) acts presynaptically to increase mIPSC frequency without altering quantal amplitude, mIPSC kinetics, or postsynaptic passive membrane properties in mouse Cajal-Retzius cells^[1].
CGP55845 (1 µM) increases GABA release probability, reducing paired-pulse ratio and failure rate while attenuating paired-pulse correlation in mouse Cajal-Retzius cell GABAergic synapses^[1].
CGP55845 (1 µM) reduces paired-pulse ratio across extracellular Ca²⁺ concentrations but does not change late eIPSC quantal amplitude in mouse Cajal-Retzius cells^[1].
CGP 55845 (0.03-0.5 μM) is the most potent GABA_B receptor antagonist tested in the hemisected rat spinal cord monosynaptic reflex assay, with an apparent K_d of 30.2 nM against (R)-Baclofen (HY-17354)-induced depression^[3].
0.3 μM CGP55845 is as potent as 100 μM CGP35348 (HY-103530) in reversing the inhibitory effects of (R)-Baclofen^[3].
CGP55845 (1 µM; 2-4 min) blocks IPSP_B and increases NMDA EPSP duration and charge in dentate-hilus border interneurons, permitting a delayed polysynaptic burst^[5].