1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. CGP55845 hydrochloride

CGP55845 hydrochloride 

Cat. No.: HY-103516
Handling Instructions

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research.

For research use only. We do not sell to patients.

CGP55845 hydrochloride Chemical Structure

CGP55845 hydrochloride Chemical Structure

CAS No. : 149184-22-5

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Description

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research[1][2].

In Vitro

In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cdkl5 +/Y and Cdkl5 -/Y male mice (2-month-old)[1]
Dosage: 0.5 mg/kg
Administration: i.p.; once
Result: Altered NOR recognition memory in Cdkl5 -/Y mice
Molecular Weight

438.71

Formula

C₁₈H₂₃Cl₃NO₃P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CGP55845 hydrochloride
Cat. No.:
HY-103516
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