2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CGP35348

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.

For research use only. We do not sell to patients.

CGP35348 Chemical Structure

CGP35348 Chemical Structure

CAS No. : 123690-79-9

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in Water USD 143 In-stock
Oil
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 450 In-stock
50 mg USD 720 In-stock
100 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].

In Vivo

CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight male Wistar rats[3]
Dosage: 100, 300, and 900 mg/kg 
Administration: Intraperitoneally given
Result: Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
Molecular Weight

225.22

Formula

C8H20NO4P
CAS No.
Appearance

Oil

Color

Off-white to light yellow

SMILES

O=P(C(OCC)OCC)(CCCN)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (369.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4401 mL 22.2005 mL 44.4010 mL
5 mM 0.8880 mL 4.4401 mL 8.8802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (111.00 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.4401 mL 22.2005 mL 44.4010 mL 111.0026 mL
5 mM 0.8880 mL 4.4401 mL 8.8802 mL 22.2005 mL
10 mM 0.4440 mL 2.2201 mL 4.4401 mL 11.1003 mL
15 mM 0.2960 mL 1.4800 mL 2.9601 mL 7.4002 mL
20 mM 0.2220 mL 1.1100 mL 2.2201 mL 5.5501 mL
25 mM 0.1776 mL 0.8880 mL 1.7760 mL 4.4401 mL
30 mM 0.1480 mL 0.7400 mL 1.4800 mL 3.7001 mL
40 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7751 mL
50 mM 0.0888 mL 0.4440 mL 0.8880 mL 2.2201 mL
60 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8500 mL
80 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
100 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CGP35348 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP35348123690-79-9CGP 35348CGP-35348GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorbrain penetrantcentrallyactiveGABABneuromuscularspatial learningneonatal damageInhibitorinhibitorinhibit

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