1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. CGP35348

CGP35348 

Cat. No.: HY-103530
Handling Instructions

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.

For research use only. We do not sell to patients.

CGP35348 Chemical Structure

CGP35348 Chemical Structure

CAS No. : 123690-79-9

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Description

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].

In Vivo

CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges. Both behavioural and electroencephalogram (EEG) parameters contributed to the establishment of a hypnotic effect. The highest dose of CGP 35348 was not effective in promoting REM sleep. The REM-sleep-enhancing effects might have theoretical and clinical relevance.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight male Wistar rats[3]
Dosage: 100, 300, and 900 mg/kg 
Administration: Intraperitoneally given
Result: Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
Molecular Weight

225.22

Formula

C₈H₂₀NO₄P

CAS No.
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CGP35348
Cat. No.:
HY-103530
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