2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CGP35348

CGP35348 

Cat. No.: HY-103530 Purity: ≥98.0%
COA Handling Instructions

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.

For research use only. We do not sell to patients.

CGP35348 Chemical Structure

CGP35348 Chemical Structure

CAS No. : 123690-79-9

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in Water USD 143 In-stock
Oil
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 450 In-stock
50 mg USD 720 In-stock
100 mg USD 1150 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].

In Vivo

CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight male Wistar rats[3]
Dosage: 100, 300, and 900 mg/kg 
Administration: Intraperitoneally given
Result: Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
Molecular Weight

225.22

Appearance

Oil

Formula

C8H20NO4P
CAS No.
SMILES

O=P(C(OCC)OCC)(CCCN)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (369.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4401 mL 22.2005 mL 44.4010 mL
5 mM 0.8880 mL 4.4401 mL 8.8802 mL
10 mM 0.4440 mL 2.2201 mL 4.4401 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (111.00 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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CGP35348 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CGP35348123690-79-9CGP 35348CGP-35348GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorbrain penetrantcentrallyactiveGABABneuromuscularspatial learningneonatal damageInhibitorinhibitorinhibit

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