123690-79-9
123690-79-9
Chemical Structure
CGP35348
- CAS No.: 123690-79-9
- Formula:C8H20NO4P
- Molecular Weight:225.22
IUPAC Name: (3-aminopropyl)(diethoxymethyl)phosphinic acid
InChIKey: QIIVUOWTHWIXFO-UHFFFAOYSA-N
SMILES: O=P(C(OCC)OCC)(CCCN)O
Biological Activity: CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CGP35348 | 98.0% | CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CGP35348 (Standard) | ≥98% | CGP35348 (Standard) is the analytical standard of CGP35348. This product is intended for research and analytical applications. CGP 35348?is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM.?CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.74
HY-121599CGP 36742 -
Similarity Score 0.74
HY-103518CGP36216 -
Similarity Score 0.74
HY-103518ACGP36216 hydrochloride -
Similarity Score 0.71
HY-129710CGP47656 -
Similarity Score 0.71
HY-W128759R4,4-Diethoxy-N,N-dimethyl-1-butanamine (Standard) -
Similarity Score 0.71
HY-100915SKF 97541 -
Similarity Score 0.70
HY-W0103542,2-Diethoxyethanol -
Similarity Score 0.69
HY-W0185024-Aminobutylphosphonic acid -
Similarity Score 0.69
HY-W145525DL-Glyceraldehyde diethyl acetal -
Explore the MedChemAI to find more analogs
References
- [1]. H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors [Content Brief]
- [2]. Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. [Content Brief]
