CGP36216 hydrochloride
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders.
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- CAS. Nr.: 1781834-71-6
- Formel: C5H15ClNO2P
- Molecular Weight:187.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
CGP36216 is ineffective at GABA postsynaptic receptors, it is appreciably more active at presynaptic receptors[2].
CGP36216 (100 µM) could increase the frequency of spontaneous firing in VTA-DA neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
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Animal Model:Rats[3].
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Dosage:20 μg/Rat.
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Administration:Intra-VTA injection (ventral tegmental area).
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Result:Abolishes CPP induced by intra-VTA injection of morphine.
Chemical Information
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CAS. Nr. 1781834-71-6
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Molecular Weight 187.60
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Formel C5H15ClNO2P
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SMILES
O=P(CC)(CCCN)O.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (266 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [Content Brief]
[3]. Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CGP36216 hydrochloride Related Classifications
HY-103518A Related Classifications
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