CGP36216 hydrochloride
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders.
For research use only. We do not sell to patients.
- CAS No.: 1781834-71-6
- Formula: C5H15ClNO2P
- Molecular Weight:187.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CGP36216 is ineffective at GABA postsynaptic receptors, it is appreciably more active at presynaptic receptors[2].
CGP36216 (100 µM) could increase the frequency of spontaneous firing in VTA-DA neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[3].
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Dosage:20 μg/Rat.
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Administration:Intra-VTA injection (ventral tegmental area).
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Result:Abolishes CPP induced by intra-VTA injection of morphine.
Chemical Information
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CAS No. 1781834-71-6
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Molecular Weight 187.60
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Formula C5H15ClNO2P
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SMILES
O=P(CC)(CCCN)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [Content Brief]
[3]. Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP36216 hydrochloride Related Classifications
HY-103518A Related Classifications
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