1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. CGP 36742

CGP 36742  (Synonyms: SGS-742)

Cat. No.: HY-121599 Purity: ≥98.0%
COA Handling Instructions

CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression.

For research use only. We do not sell to patients.

CGP 36742 Chemical Structure

CGP 36742 Chemical Structure

CAS No. : 123690-78-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 132 In-stock
Solution
10 mM * 1 mL in Water USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 215 In-stock
25 mg USD 400 In-stock
50 mg USD 680 In-stock
100 mg USD 1090 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].

IC50 & Target

IC50: 32 μM (GABAB)[1]

Molecular Weight

179.20

Formula

C7H18NO2P

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=P(CCCN)(O)CCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (697.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5804 mL 27.9018 mL 55.8036 mL
5 mM 1.1161 mL 5.5804 mL 11.1607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5804 mL 27.9018 mL 55.8036 mL 139.5089 mL
5 mM 1.1161 mL 5.5804 mL 11.1607 mL 27.9018 mL
10 mM 0.5580 mL 2.7902 mL 5.5804 mL 13.9509 mL
15 mM 0.3720 mL 1.8601 mL 3.7202 mL 9.3006 mL
20 mM 0.2790 mL 1.3951 mL 2.7902 mL 6.9754 mL
25 mM 0.2232 mL 1.1161 mL 2.2321 mL 5.5804 mL
30 mM 0.1860 mL 0.9301 mL 1.8601 mL 4.6503 mL
40 mM 0.1395 mL 0.6975 mL 1.3951 mL 3.4877 mL
50 mM 0.1116 mL 0.5580 mL 1.1161 mL 2.7902 mL
60 mM 0.0930 mL 0.4650 mL 0.9301 mL 2.3251 mL
80 mM 0.0698 mL 0.3488 mL 0.6975 mL 1.7439 mL
100 mM 0.0558 mL 0.2790 mL 0.5580 mL 1.3951 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CGP 36742
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