1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. 3-Aminopropylphosphinic acid

3-Aminopropylphosphinic acid (Synonyms: 3-APPA; CGP 27492; CGA 147823)

Cat. No.: HY-115763
Handling Instructions

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist.

For research use only. We do not sell to patients.

3-Aminopropylphosphinic acid Chemical Structure

3-Aminopropylphosphinic acid Chemical Structure

CAS No. : 103680-47-3

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Description

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist[1].

IC50 & Target

GABAB[1]

In Vitro

3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84-0.23 μM)[2]
3-Aminopropylphosphinic acid acts as an anti-aging substance for skin[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

3-Aminopropylphosphinic acid (5 mg/kg; i.v.) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: guinea pigs[3]
Dosage: 5 mg/kg
Administration: IV
Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm.
Molecular Weight

123.09

Formula

C₃H₁₀NO₂P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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3-Aminopropylphosphinic acid
Cat. No.:
HY-115763
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