3-Aminopropylphosphinic acid
3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist.
For research use only. We do not sell to patients.
- CAS No.: 103680-47-3
- Formula: C3H10NO2P
- Molecular Weight:123.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
GABAB[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
19 nM
Compound: 1
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Agonist activity at human recombinant GABABreceptor expressed in CHO-K1 cells assessed as inhibition of intracellular calcium release by FLIPR
Agonist activity at human recombinant GABABreceptor expressed in CHO-K1 cells assessed as inhibition of intracellular calcium release by FLIPR
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[PMID: 18578471] |
In Vitro
3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84-0.23 μM)[2]
3-Aminopropylphosphinic acid acts as an anti-aging substance for skin[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:guinea pigs[3]
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Dosage:5 mg/kg
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Administration:IV
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Result:Blocked the inhibitory effects of GABA against vagal broncho-spasm.
Chemical Information
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CAS No. 103680-47-3
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Molecular Weight 123.09
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Formula C3H10NO2P
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SMILES
O=P(CCCN)O
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Synonyms
3-APPA; CGP 27492; CGA 147823
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9. [Content Brief]
[2]. Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6. [Content Brief]
[3]. Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Aminopropylphosphinic acid Related Classifications
HY-115763 Related Classifications
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