3-Aminopropylphosphinic acid (Synonyms: 3-APPA; CGP 27492; CGA 147823)

Cat. No.: HY-115763: FAQs
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3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABA_B receptor agonist.

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3-Aminopropylphosphinic acid Chemical Structure

CAS No. : 103680-47-3

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Description

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABA_B receptor agonist^[1].

IC₅₀ & Target

GABAB^[1]

In Vitro

3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC₅₀=1.84-0.23 μM)^[2]
3-Aminopropylphosphinic acid acts as an anti-aging substance for skin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

3-Aminopropylphosphinic acid (5 mg/kg; i.v.) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	guinea pigs^[3]
Dosage:	5 mg/kg
Administration:	IV
Result:	Blocked the inhibitory effects of GABA against vagal broncho-spasm.

Molecular Weight

123.09

Formula

C₃H₁₀NO₂P

CAS No.

103680-47-3

SMILES

O=P(CCCN)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9. [Content Brief]

[2]. Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6. [Content Brief]

[3]. Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24. [Content Brief]

[4]. Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid); a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895.

3-Aminopropylphosphinic acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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