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Cat. No.: HY-175263

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Aminochalcone 4AAF

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT_3A and 5-HT_2C receptors, and stimulates allosteric behavior toward the 5-HT_2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures.

For research use only. We do not sell to patients.

CAS No.: 38239-51-9
Formula: C₁₅H₁₃NO
Molecular Weight:223.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Aminochalcone 4AAF Chemical Structure

CAS No.: 38239-51-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	8.5 μM Compound: 8a	Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
DLD-1	EC₅₀	33 μM Compound: 14	Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
FHC	CC₅₀	>100 μM Compound: 14	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
FM3A	IC₅₀	34 μM Compound: 8a	Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
HCT-116	EC₅₀	23 μM Compound: 14	Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	EC₅₀	27 μM Compound: 14	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	IC₅₀	14.1 μM Compound: 1	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
HeLa	IC₅₀	7.7 μM Compound: 8a	Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
HL-60	IC₅₀	6.4 μM Compound: 1	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
HT-29	EC₅₀	35 μM Compound: 14	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
L1210	IC₅₀	14 μM Compound: 8a	Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
MOLT-4	IC₅₀	7.9 μM Compound: 8a	Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
OVCAR-8	IC₅₀	>22.4 μM Compound: 1	Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
PBMC	IC₅₀	20.2 μM Compound: 1	Cytotoxicity against human PBMC cells after 72 hrs by MTT assay Cytotoxicity against human PBMC cells after 72 hrs by MTT assay	10.1039/C4MD00371C
SF-295	IC₅₀	>22.4 μM Compound: 1	Cytotoxicity against human SF295 cells after 72 hrs by MTT assay Cytotoxicity against human SF295 cells after 72 hrs by MTT assay	10.1039/C4MD00371C

In Vivo

Aminochalcone 4AAF (20 μL of 0.1-10 mg/mL, p.o., single dose) shows anxiolytic and hypoglycemic effects, reversing sucrose-induced anxiety and hyperglycemia in adult zebrafish and delaying the clonic stage of the epileptic crisis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult zebrafish aged between 90 and 120 days, measuring approximately 3.5 cm in length and weighing approximately 0.4 g^[1]
Dosage:

20 μL of 0.1, 0.5, or 10 mg/mL
Administration:

p.o. for a single dose
Result:

Showed not toxicity to adult zebrafish (LC₅₀ > 1.0 mg/mL).
Exhibited anxiolytic behavior in novel tank test.
Caused a significant impairment of motor function in open field test and spinning task.
Altered the latency time and the number of crossings between the light and dark sides.
Restored the locomotor pattern when pretreated with Flumazenil (HY-B0009) (0.1 mg/mL).
Reduced the time the fish spent in the light area of the aquarium when pretreated with Cyproheptadine (HY-B1622), Pizotifen (HY-B0115), and Granisetron (HY-B0071).
Increased latency time and reduced the number of crossings from the light to the dark.
Prevented hyperglycemia-induced oxidative stress in liver and brain tissues of adult zebrafish (0.5 mg/mL).
Reversed PTZ-induced convulsive behavior in stage three (1.0 mg/mL).

Chemical Information

CAS No. 38239-51-9
Molecular Weight 223.27
Formula C₁₅H₁₃NO
SMILES

NC1=CC=C(C=C1)C(/C=C/C2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bezerra AS, et al. Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish. ACS Omega. 2025 Jul 14;10(28):30313-30326. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Aminochalcone 4AAF

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Aminochalcone 4AAF Related Classifications

HY-175263 Related Classifications