U-89843A hydrochloride
U-89843A (PNU-89843) hydrochloride is a GABAA receptors positive allosteric modulator (PAM). U-89843A hydrochloride enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. U-89843A hydrochloride shows antioxidant and sedative effects.
For research use only. We do not sell to patients.
- CAS No.: 157013-85-9
- Formula: C16H24ClN5
- Molecular Weight:321.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GABAA receptor[1]
Chemical Information
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CAS No. 157013-85-9
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Molecular Weight 321.85
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Formula C16H24ClN5
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SMILES
CN1C(C)=CC2=C(N3CCCC3)N=C(N4CCCC4)N=C21.[H]Cl
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Synonyms
PNU-89843 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Im HK, Im WB, et al. U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. J Pharmacol Exp Ther. 1995 Dec;275(3):1390-5. [Content Brief]
[2]. Bundy GL, et al. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J Med Chem. 1995 Oct 13;38(21):4161-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-89843A hydrochloride Related Classifications
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