2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GHR

GHR

Growth Hormone Receptor; Somatotropin Receptor; Growth Hormone Binding Protein (GHBP)

Growth hormone (GH), also known as somatotropin, promotes body growth by binding with two GH receptors (GHRs) at the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription activators to stimulate metabolic effects and insulin-like growth factor (IGF) synthesis. However, process dysfunctions in the GH–GHR–IGF-1 axis cause animal dwarfism. If, during the GH process, GHR is not successfully recognized and/or bound, or GHR fails to transmit the GH signal to IGF-1, the GH dysfunction occurs.

GHR Related Products (28):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0089A
    Human growth hormone-releasing factor TFA
    		Activator 99.49%
    Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.
    Human growth hormone-releasing factor TFA
  • HY-P3304
    MR 409
    		Agonist 99.98%
    MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer.
    MR 409
  • HY-P3397A
    JV-1-36 acetate
    		Antagonist 99.93%
    JV-1-36 acetate is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 acetate inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .
    JV-1-36 acetate
  • HY-164419A
    Atesidorsen sodium
    		Inhibitor 98.58%
    Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA
    Atesidorsen sodium
  • HY-131514
    L-Ornithine 2-oxoglutarate
    		Activator
    L-Ornithine 2-oxoglutarate (Ornithine alpha-ketoglutarate) is a nutritional compound that is a salt of amino acids with antioxidant and anti-inflammatory effects. L-Ornithine 2-oxoglutarate stimulates the production of insulin and growth hormone, and promotes intracellular amino acid transport and protein synthesis.
    L-Ornithine 2-oxoglutarate
  • HY-153485C
    Cimdelirsen sodium scrambled negative control
    		Inhibitor
    Cimdelirsen sodium scrambled negative control is the sequence scrambled negative control of Cimdelirsen sodium.
    Cimdelirsen sodium scrambled negative control
  • HY-159697B
    ISIS 532401 sodium scrambled negative control
    ISIS 532401 sodium scrambled negative control is the sequence scrambled negative control of ISIS 532401 sodium.
    ISIS 532401 sodium scrambled negative control
  • HY-P0089
    Human growth hormone-releasing factor
    		Activator 98.63%
    Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.
    Human growth hormone-releasing factor
  • HY-P1460
    His-[D-2-ME-Trp]-Ala
    		99.92%
    His-[D-2-ME-Trp]-Ala is a fragment of the growth hormone hexarelin.
    His-[D-2-ME-Trp]-Ala
  • HY-RS05413
    GHRH Human Pre-designed siRNA Set A

    GHRH Human Pre-designed siRNA Set A contains three designed siRNAs for GHRH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    GHRH Human Pre-designed siRNA Set A
  • HY-159697A
    ISIS 532401 sodium
    ISIS 532401 sodium is an oligonucleotide that can target GHr.
    ISIS 532401 sodium
  • HY-159697
    ISIS 532401
    ISIS 532401 is an oligonucleotide that can target GHr.
    ISIS 532401
  • HY-P3594
    [His1,Nle27] GHRF (1-32), amide, human
    		Activator
    [His1,Nle27] GHRF (1-32), amide, human is a Growth hormone releasing hormone (GHRH) analog. [His1,Nle27] GHRF (1-32), amide, human has great receptor affinity for GHRHR.
    [His1,Nle27] GHRF (1-32), amide, human
  • HY-153485
    Cimdelirsen
    		Inhibitor
    Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
    Cimdelirsen
  • HY-P3595
    GHRF, porcine
    		Activator
    GHRF, porcine is a growth hormone releasing factor (GHRF) peptide (porcine). GHRF binds to GHSR and induces the release of growth hormone.
    GHRF, porcine
  • HY-164419
    Atesidorsen
    		Inhibitor
    Atesidorsen is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA
    Atesidorsen
  • HY-153485A
    Cimdelirsen sodium
    		Inhibitor
    Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
    Cimdelirsen sodium
  • HY-P3397
    JV-1-36
    		Antagonist
    JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .
    JV-1-36
  • HY-RS05412
    GHR Human Pre-designed siRNA Set A
    		Inhibitor

    GHR Human Pre-designed siRNA Set A contains three designed siRNAs for GHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    GHR Human Pre-designed siRNA Set A
  • HY-RS23191
    Ghrh Rat Pre-designed siRNA Set A

    Ghrh Rat Pre-designed siRNA Set A contains three designed siRNAs for Ghrh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ghrh Rat Pre-designed siRNA Set A