JV-1-36
JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .
For research use only. We do not sell to patients.
- CAS No.: 221377-79-3
- Formula: C172H284ClN53O41
- Molecular Weight:3785.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: growth hormone-releasing hormone (GHRH)[1].
JV-1-36 (0.01-15 μM; 8 h) reduces cell viability in A549 cells at higher concentrations (5-15 μM), and (2-15 μM; 8 h) also decreases cell viability in Hela cells[1].
JV-1-36 (1 μM; 8 h) significantly reduces the production of ROS induced by H2O2 (0.1 mM; 8 h) in A549 lung cancer cells, exerting antioxidant effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 221377-79-3
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Molecular Weight 3785.88
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Formula C172H284ClN53O41
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Sequence
{N-(2-phenylacetyl)}-Tyr-{d-Arg}-Asp-Ala-Ile-{4-Cl-Phe}-Thr-Asn-{Har}-{Tyr(Me)}-Arg-Lys-Val-Leu-{Abu}-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-{Nle}-{d-Arg}-{Har}-NH2
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Sequence Shortening
{N-(2-phenylacetyl)}-Y-{d-Arg}-DAI-{4-Cl-Phe}-TN-{Har}-{Tyr(Me)}-RKVL-{Abu}-QLSARKLLQDI-{Nle}-{d-Arg}-{Har}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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