Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-16194

Emiglitate	Inhibitor	98.0%
Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.

HY-N1218

Stellasterol	Inhibitor
Stellasterol is a natural product. Stellasterol has high affinity towards Bcl-2 protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor.

HY-N4309

Lotusine	Inhibitor	99.91%
Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC₅₀ of 30.60 μg/mL against α-amylase and an IC₅₀ of 36.15 μg/mL against α-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G₀/G₁ cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder.

HY-N12247

2-Methylbutyl β-D-glucopyranoside	Substrate	98.0%
2-Methylbutyl β-D-glucopyranoside is a glycoside in apple fruit. 2-Methylbutyl β-D-glucopyranoside serves as an aroma precursor that can be enzymatically hydrolyzed to release volatile 2-methylbutanol. 2-Methylbutyl β-D-glucopyranoside is promising for research of food flavor chemistry.

HY-W002011R

Quinoline-2-carboxylic acid (Standard)	Inhibitor
Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds.

HY-N3256

Millewanin H	Inhibitor
Millewanin H is a Flavonoids product that can be isolated from the herbs of Millettia pachycarpa. Millewanin H has antiestrogenic activity and inhibit 17β-estradiol-induced-β-galactosidase activity. Millewanin H showes α-glucosidase inhibition.

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard)	Inhibitor
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects.

HY-156287

GCase modulator-1	Modulator
GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC₅₀=2.23 μM).

HY-162373

α-Amylase/α-Glucosidase-IN-10	Inhibitor
α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC₅₀: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects.

HY-14929

Migalastat	Inhibitor
Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC₅₀ value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.

HY-N1839

3-Hydroxybakuchiol	Inhibitor
3-Hydroxybakuchiol can be isolated from Otholobium mexicanum J. W. Grimes. 3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor. 3-Hydroxybakuchiol has antitumor activity, and induces tumor cell apoptosis. 3-Hydroxybakuchiol also has moderate inhibitory activity against α-glucosidase (IC₅₀: 345 μM).

HY-145274

EB-0156	Inhibitor
EB-0156 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC₅₀s of 0.0479 and less than 0.001 μM, respectively. EB-0156 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0156 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses.

HY-149151

Variegatic acid	Inhibitor
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

HY-182776

α-Glucosidase-IN-115	Inhibitor
α-Glucosidase-IN-115 (compound 3m) is a non-competitive α-Glucosidase inhibitor with an IC₅₀ value of 45.07 μM. α-Glucosidase-IN-115 is applicable to the research of type 2 diabetes.

HY-165100

1,3-Dipalmitoleoyl glycerol	Inhibitor
1,3-Dipalmitoleoyl glycerol (DG(16:1/0:0/16:1)) is a compound isolated from sea cucumber viscera, which has α-glucosidase inhibitory activity and has different degrees of inhibitory effects on α-glucosidase from different sources.

HY-E70889

β-Xylosidase(thermostable)
β-Xylosidase (thermostable) can release reducing sugars from birch xylan and catalyze the hydrolysis of 4-methylumbelliferone-β-D-cellobiose and 4-methylumbelliferone-β-D-glucopyranoside. β-Xylosidase does not possess endoxylanase, arabinoxylanase, or β-glucanase activity. β-Xylosidase undergoes post-translational glycosylation modification.

HY-154995

N-4′-(p-Trifluoromethylphenyl)butyl-DAB	Inhibitor
N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) is an agonit of lysosomal acid α-glucosidase (GAA). N-4′-(p-Trifluoromethylphenyl)butyl-DAB increases intracellular GAA activities dose-dependently, in Pompe patient's fibroblasts with the M519V mutation.

HY-161421

α-Glucosidase-IN-61	Inhibitor
α-Glucosidase-IN-61 (Compd 1j), a competitive α-glucosidase inhibitor, demonstrates excellent inhibition with an IC₅₀ of 0.73 μM. α-Glucosidase-IN-61 (Compd 1j) is used for the research of type 2 diabetes mellitus.

HY-153922

N-Octyl-α-4-epivalienamine	Activator
N-Octyl-α-4-epivalienamine is an orally active and CNS-penetrant molecular chaperone that induces high expression of the deficient β-galactosidase activity. N-Octyl-α-4-epivalienamine ameliorates symptoms and increase survival rate in a mouse model of G_M1-gangliosidosis. N-Octyl-α-4-epivalienamine can be used for neurogenetic disease research.

HY-159796A

Cefetecol	Inhibitor
Ceftezole (GR69153) is a broad-spectrum cephalosporin antibiotic and an α-glucosidase inhibitor. Ceftezole inhibits bacterial cell lysis by inhibiting cell wall synthesis and binding to penicillin-binding proteins (PBPs). Ceftezole exhibits in vivo anti-diabetic activity in diabetic mice. Ceftezole can be used in antibacterial and anti-diabetic research.

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):