Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-151143

α-Glucosidase-IN-19	Inhibitor
α-Glucosidase-IN-19 (Compound 6B) is a potent, orally active α-glucosidase inhibitor with an IC₅₀ of 3.63 μM. α-Glucosidase-IN-19 shows anti-diabetic activity.

HY-N9051

6-Prenylquercetin-3-Me ether	Inhibitor
6-Prenylquercetin-3-Me ether is a natural product that can be extracted from G. uralensis leaves. 6-Prenylquercetin-3-Me ether has radical scavenging activity toward DPPH. 6-Prenylquercetin-3-Me ether also has inhibitory activity against α-glucosidase.

HY-150959

α-Glucosidase-IN-12	Inhibitor
α-Glucosidase-IN-12 (compound 14) is a potent α-glucosidase inhibitor, with an IC₅₀ of 10.20 μM.

HY-182311

ALR2/α-Glucosidase-IN-1	Inhibitor
ALR2/α-Glucosidase-IN-1 (Compound 4) is a competitive ALR2 inhibitor and competitive α-glucosidase inhibitor, with an IC₅₀ of 0.250 μM against ALR2 and an IC₅₀ of 0.561 μM against α-glucosidase. ALR2/α-Glucosidase-IN-1 binds to the active sites of ALR2 and α-glucosidase, and inhibits enzymatic activity by competing with their respective substrates. ALR2/α-Glucosidase-IN-1 can be used in diabetes-related research.

HY-175170

α-Glucosidase-IN-95	Inhibitor
α-Glucosidase-IN-95 (Compound 21c) is a competitive α-Glucosidase inhibitor with an IC₅₀ of 0.44  μM. α-Glucosidase-IN-95 has a significant inhibitory potency without cytotoxicity to normal cells. α-Glucosidase-IN-95 can be used for metabolic disorders like diabetes mellitus research.

HY-N6575

7β-Hydroxybufalin	Inhibitor
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase.

HY-168462

α-Glucosidase-IN-82	Inhibitor
α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-Glucosidase, with the IC₅₀ of 13.66 μM. α-Glucosidase-IN-82 exhibits a 52-fold increase in inhibitory activity relative to Acarbose (HY-B0089).

HY-119593

α-Homonojirimycin	Inhibitor
α-Homonojirimycin is a potent α-glucosidase inhibitor.

HY-162673

α-Amylase/α-Glucosidase-IN-16	Inhibitor
α-Amylase/α-Glucosidase-IN-16 (compound 15) is a potent dual inhibitor of α-amylase and α-Glucosidase with IC₅₀ values of 0.8 and 1.2 μM, respectively. α-Amylase/α-Glucosidase-IN-16 can be used in the study of diabetes mellitus (DM).

HY-156380

α-Amylase/α-Glucosidase-IN-6	Inhibitor
α-Amylase/α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC₅₀s of 17.0 and 40.1 µM, respectively. α-Amylase/α-Glucosidase-IN-6 exhibits anti-hyperglycemic activities.

HY-P2763A

β-Glucanase 2(thermostable)
β-Glucanase 2(thermostable) is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). β-Glucanase 2 (thermostable) is an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-179154

α-Glucosidase-IN-101	Inhibitor
α-Glucosidase-IN-101 (Compound 13j) is an uncompetitive α-glucosidase inhibitor, with an IC₅₀ of 120 nM. α-Glucosidase-IN-101 properly inhibits CYP1A2, CYP2C19, and CYP2C9 isoforms of cytochrome P450. α-Glucosidase-IN-101 can be used in the research of diabetes.

HY-172757

α-Glucosidase-IN-88	Inhibitor
α-Glucosidase-IN-88 (Compound 3K) is an orally active and potent α-glucosidase inhibitor with an IC₅₀ value of 6.40 µM. α-Glucosidase-IN-88 inhibits carbohydrate hydrolysis by blocking the enzyme's ability to break down glycosidic bonds, thereby reducing postprandial blood glucose levels. α-Glucosidase-IN-88 is promising for research of type 2 diabetes mellitus (T2DM).

HY-W009417R

Cedryl acetate (Standard)	Inhibitor
Cedryl acetate (Standard) is the analytical standard of Cedryl acetate. This product is intended for research and analytical applications. Cedryl acetate is an orally active α-glucosidase inhibitor with an IC₅₀ of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome.

HY-N17439

4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one	Inhibitor
4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one is a naphthalene derivative and a weak α-glucosidase inhibitor. 4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one can be found in the leaves of Cyclocarya paliurus. 4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one can be used for the research of diabetes.

HY-179511

α-Glucosidase-IN-104	Inhibitor
α-Glucosidase-IN-104 (Compound 9s) is an efficient inhibitor of α-glucosidase with an IC₅₀ of 24.32 μM. α-Glucosidase-IN-104 has a weak inhibitory effect on α-amylase and avoids gastrointestinal side effects. α-Glucosidase-IN-104 can be used for research on type 2 diabetes.

HY-144124

5-C-heptyl-DNJ	Inhibitor
5-heptyl-DNJ is a potent GAA agonist with a K_i of 0.0047 μM. 5-C-heptyl-DNJ increases GAA activities by chaperrone effects.

HY-182898

Gal-dMor-Gem
Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence.

HY-P2763B

β-Glucanase 1(thermostable)
β-Glucanase 1(thermostable) is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). β-Glucanase 1 (thermostable) is an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-151138

α-Glucosidase-IN-16	Inhibitor
α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic activity.

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):