Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-161281

α-Glucosidase-IN-49	Inhibitor
α-Glucosidase-IN-49 (compound C23) is a potent inhibitor of α-Glucosidase, with IC₅₀ of 0.52 μM. α-Glucosidase-IN-49 has oral bioactivity that can reduce blood glucose and improve glucose tolerance in mice.

HY-178138

α-Glucosidase-IN-97	Inhibitor
α-Glucosidase-IN-97 (Compound 9i) is a highly selective α-glucosidase inhibitor (IC₅₀=1.05 μM). α-Glucosidase-IN-97 is promising for research of type 2 diabetes mellitus (T2DM).

HY-161411

α-Glucosidase-IN-60	Inhibitor
α-Glucosidase-IN-60 (Compound 5k) exhibits a competitive inhibitory efficacy against α-Glucosidase, with IC₅₀ of 10.8 μM.

HY-168074

4″-C18 EGCG	Inhibitor
4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC₅₀ values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM.

HY-169251

α-Glucosidase-IN-75	Inhibitor
α-Glucosidase-IN-75 (compound 13) is an α-glucosidase inhibitor with an IC₅₀ of 3.81 μM. α-Glucosidase-IN-75 can be used for the study of high glucose-induced cardiovascular diseases.

HY-163279

Fluopipamine	Antagonist
Fluopipamine is an antagonist for Cellulose Synthase 1 (CESA1) with an IC₅₀ of 0.78 μM. Fluopipamine leads a decrease in glucose uptake into cellulose and hyperaccumulation of CESAs at the PM in etiolated Arabidopsis seedlings.

HY-146984

α-Amylase-IN-2	Inhibitor
α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivative against α-glucosidase (IC₅₀=1.28 µM) and α-amylase (IC₅₀=3.8 µM) .

HY-P2775A

β-Glucosidase(thermostable)
β-Glucosidase(thermostable) is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). β-Glucosidase(thermostable) is an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-178200

5-C-phenethyl-DNJ hydrochloride	Activator
5-C-phenethyl-DNJ hydrochloride is an orally active acid α-glucosidase (GAA) activator. 5-C-phenethyl-DNJ hydrochloride can increase GAA activity in various tissues, particularly in the diaphragm. 5-C-phenethyl-DNJ hydrochloride can be used for the research of metabolic disease, such as Pompe disease.

HY-P2858C

β-Mannosidase, Bacteroides fragilis
β-Mannosidase, Bacteroides fragilis (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.

HY-N2703

6β-Hydroxyipolamiide	Inhibitor
6β-Hydroxyipolamiide can be isolated from the methanolic extract of S. jamaicensis leaves. 6β-Hydroxyipolamiide has α-glucosidase inhibitory activity with an IC₅₀ of 539.17 μg/mL.

HY-N9134

5-O-Methylgenistein	Inhibitor
5-O-Methylgenistein (Isoprunetin) is an isoflavone that can be isolated from M. amurensis wood. 5-O-Methylgenistein inhibits β-gal activityy induced by 17β-Estradiol (HY-B0141) in yeast.

HY-100127

ML247
ML247 is a non-inhibitory and selective small molecule chaperone of acid alpha glucosidase. ML247 can be used for the research of metabolic disease, such as Pompe disease.

HY-162639

α-Glucosidase-IN-68	Inhibitor
α-Glucosidase-IN-68 (Compound 2) is an inhibitor for α-Glucosidase, AChE, and BChE, with IC₅₀ of 0.251, 0.774 and 0.793 μM, respectively. α-Glucosidase-IN-68 exhibits antioxidant efficacy, with IC₅₀ of 0.69 μM and 0.02 μM, in DPPH and ABTS experiments. α-Glucosidase-IN-68 exhibits antidiabetic effect in Streptozotocin (HY-13753)-induced diabetic rat models.

HY-E71305E

β-Glucosidase 1A, Pyrococcus furiosus
β-Glucosidase 1A, Pectobacterium carotovorum (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-115978

α-Glucosidase-IN-2	Inhibitor
α-Glucosidase-IN-2 (compound 5d) is a potent α-Glucosidase inhibitor with an IC₅₀ of 9.48 µM. α-Glucosidase-IN-2 is an antidiabetic agent.

HY-N13137

Timosaponin N	Inhibitor
Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research.

HY-161469

α-Amylase/α-Glucosidase-IN-13	Inhibitor
α-Amylase/α-Glucosidase-IN-13 (Compound 5d) is a dual inhibitor of α-Amylase/α-Glucosidase that can be used for diabetes research.

HY-162390

α-Amylase/α-Glucosidase-IN-11	Inhibitor
α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC₅₀ = 30.39 μM) and α-glucosidase (IC₅₀ = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier.

HY-146225

α-Amylase/α-Glucosidase-IN-2	Inhibitor
α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC₅₀ values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):