2. Signalwege
  3. Epigenetics
  4. Histone Acetyltransferase
  5. MOZ/MORF Isoform

MOZ/MORF

MOZ (KAT6A) and MORF (KAT6B) are paralogous members of the MYST family of lysine acetyltransferases that function in multisubunit chromatin-regulatory complexes and catalyze histone H3 acetylation to promote transcriptionally active chromatin states[1][2]. Mechanistically, MOZ/MORF complexes interact with BRPF and ING proteins, integrate histone-reader functions with catalytic activity, and regulate chromatin-dependent gene expression programs involved in development, stem-cell maintenance, and hematopoiesis[1][3][4]. Recent structural and genomic studies further demonstrated that MOZ and MORF recognize unmethylated CpG-rich promoter regions through N-terminal winged-helix domains, facilitating promoter targeting, H3K23 acetylation, and transcriptional activation[5]. These chromatin-regulatory activities are closely linked to biological processes including embryogenesis, skeletogenesis, cellular differentiation, and maintenance of hematopoietic stem-cell function[3][4][5]. Disease relevance is supported by recurrent chromosomal rearrangements involving KAT6A or KAT6B in acute myeloid leukemia and related hematologic malignancies, as well as developmental disorders associated with germline variants in either gene[2][4]. Compared with related MYST family acetyltransferases, MOZ and MORF share high sequence homology and similar domain organization, yet they function as distinct catalytic subunits within mutually exclusive complexes and can display context-dependent biological specialization[2][6]. For experimental applications, MOZ/MORF-containing complexes provide a tractable model for investigating epigenetic regulation, chromatin targeting mechanisms, and acetyltransferase-dependent transcriptional control in development and disease[1][3][5].

MOZ/MORF Verwandte Produkte (6):

Art. -Nr. Produktname Wirkung Reinheit
  • HY-132283
    PF-9363
    		Inhibitor 99.64%
    PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
  • HY-102060
    WM-8014
    		Inhibitor 99.92%
    WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM.
  • HY-102058
    WM-1119
    		Inhibitor 99.57%
    WM-1119, a chemical probe, is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively.
  • HY-102059
    MOZ-IN-2
    		Inhibitor 99.58%
    MOZ-IN-2 is an inhibitor of protein MOZ, a member of histone acetyltransferases, with an IC50 of 125 μM.
  • HY-177046
    KAT6A/KAT7-IN-4
    		Inhibitor 98.86%
    KAT6A/KAT7-IN-4 is a KAT6A and KAT7 inhibitor. KAT6A/KAT7-IN-4 has IC50 values of both ≤ 1 nM for KAT6A and KAT7. KAT6A/KAT7-IN-4 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-4 also inhibits tumor cell proliferation, with an IC50 of ≤ 100 nM for CAMA-1. KAT6A/KAT7-IN-4 can be used in the study of breast cancer.
  • HY-182775
    PROTAC KAT6 Degrader-1
    		Degrader
    PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation.