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Referencia número: HY-182775

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PROTAC KAT6 Degrader-1

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₉H₄₆FN₉O₇S
Peso molecular:803.90

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC KAT6 Degrader-1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
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Actividad biológica

Descripciòn

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation^[1].

IC₅₀ & Target^[1]

Cereblon

MOZ/MORF

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas Histone Acetyltransferase :

In Vitro

PROTAC KAT6 Degrader-1 (Compound 28) (12 nM) shows maximal fold activity ≥7.0 of ternary complex formation^[1].
PROTAC KAT6 Degrader-1 inhibits T47D cell proliferation with GI₅₀ of 10.3 nM^[1].
(Pink: target protein ligand; Blue: E3 ligase ligand; Black: linker).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 803.90
Fòrmula C₃₉H₄₆FN₉O₇S
SMILES

COC1=CC(N2CCN(CC2)CC(CC3)CCN3C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=CC=C1S(=O)(NC(C6=CC=C(C(OC)=N6)CN7C=CC=N7)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Raymond A. Ng, et al. Kat6 degrader compounds and method thereof. WO2026060321A1. 2026-03-19

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PROTAC KAT6 Degrader-1

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PROTAC KAT6 Degrader-1

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas Histone Acetyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PROTAC KAT6 Degrader-1 Related Classifications

HY-182775 Related Classifications