2. PROTAC Epigenetics
  3. PROTACs Histone Acetyltransferase
  4. PROTAC KAT6 Degrader-1

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation.

For research use only. We do not sell to patients.

PROTAC KAT6 Degrader-1

PROTAC KAT6 Degrader-1 Chemical Structure

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PROTAC KAT6 Degrader-1 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • Biological Activity

  • Purity & Documentation

  • References

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Description

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation[1].

IC50 & Target[1]

Cereblon

 

MOZ/MORF

 

In Vitro

PROTAC KAT6 Degrader-1 (Compound 28) (12 nM) shows maximal fold activity ≥7.0 of ternary complex formation[1].
PROTAC KAT6 Degrader-1 inhibits T47D cell proliferation with GI50 of 10.3 nM[1].
(Pink: target protein ligand; Blue: E3 ligase ligand; Black: linker).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC KAT6 Degrader-1 Related Antibodies
Molecular Weight

803.90

Formula

C39H46FN9O7S
SMILES

COC1=CC(N2CCN(CC2)CC(CC3)CCN3C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=CC=C1S(=O)(NC(C6=CC=C(C(OC)=N6)CN7C=CC=N7)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC KAT6 Degrader-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC KAT6 Degrader-1PROTACsHistone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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PROTAC KAT6 Degrader-1
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