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Cat. No.: HY-182775

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PROTAC KAT6 Degrader-1

Name: PROTAC KAT6 Degrader-1
Brand: MedChemExpress
SKU: HY-182775
Price: 1600.00 USD
Availability: InStock
Rating: 5 (1 reviews)

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation.

For research use only. We do not sell to patients.

Formula: C₃₉H₄₆FN₉O₇S
Molecular Weight:803.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC KAT6 Degrader-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation^[1].

IC₅₀ & Target

^[1]

Cereblon

MOZ/MORF

All PROTACs Isoforms :

All Histone Acetyltransferase Isoforms :

In Vitro

PROTAC KAT6 Degrader-1 (Compound 28) (12 nM) shows maximal fold activity ≥7.0 of ternary complex formation^[1].
PROTAC KAT6 Degrader-1 inhibits T47D cell proliferation with GI₅₀ of 10.3 nM^[1].
(Pink: target protein ligand; Blue: E3 ligase ligand; Black: linker).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 803.90
Formula C₃₉H₄₆FN₉O₇S
SMILES

COC1=CC(N2CCN(CC2)CC(CC3)CCN3C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=CC=C1S(=O)(NC(C6=CC=C(C(OC)=N6)CN7C=CC=N7)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Raymond A. Ng, et al. Kat6 degrader compounds and method thereof. WO2026060321A1. 2026-03-19

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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