2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Neprilysin

Neprilysin

Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10

Neprilysin

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Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10827
    Kelatorphan
    		Inhibitor 98.66%
    Kelatorphan is a full inhibitor of enkephalin degrading enzymes.
    Kelatorphan
  • HY-15407AS1
    Sacubitril-d4 hemicalcium salt
    		Inhibitor 98.78%
    Sacubitril-d4 hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM.
    Sacubitril-d<sub>4</sub> hemicalcium salt
  • HY-15407R
    Sacubitril (Standard)
    		Inhibitor
    Sacubitril (Standard) is the analytical standard of Sacubitril. This product is intended for research and analytical applications. Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19.
    Sacubitril (Standard)
  • HY-19876
    PL37
    		Antagonist
    PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED50 value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain.
    PL37
  • HY-17399S
    Racecadotril-d5
    		Inhibitor
    Racecadotril-d5 is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
    Racecadotril-d<sub>5</sub>
  • HY-173430
    AD015
    		Inhibitor
    AD015 is a angiotensin-converting enzyme (ACE) and neprilysin (NEP) dual inhibitor. AD015 inhibits NEP, nACE and cACE with IC50s of 0.009, 0.019 and 0.0008 μM, respectively.
    AD015
  • HY-105319
    CGS-30440
    		Inhibitor
    CGS-30440 is a potent and orally active dual inhibitor of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). CGS-30440 exhibit antihypertensive and natriuretic effects. CGS-30440 also shows protective effect for chronic renal failure. CGS-30440 can be used for the research of cardiovascular disease, such as hypertension.
    CGS-30440
  • HY-116476
    Risotilide
    		Inhibitor
    Risotilide is an inhibitor of enkephalinase B, which has the ability to inhibit enkephalinase B activity (IC50 value is 0.35 microM), and can also effectively inhibit enkephalinase A (IC50 = 0.02 microM) and aminopeptidase activity (IC50 = 13 microM), and can be regarded as a complete inhibitor of enkephalin biodegradation.
    Risotilide
  • HY-W013375S
    Thiorphan-d7
    Thiorphan-d7 is the deuterium labeled Thiorphan. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM.
    Thiorphan-d<sub>7</sub>
  • HY-P2658
    [Des-Tyr1]-Met-Enkephalin
    [Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins.
    [Des-Tyr1]-Met-Enkephalin
  • HY-170962
    SDUY817
    		Inhibitor
    SDUY817 is a dual APN/NEP inhibitor, with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. SDUY817 exerts analgesic effects in a concentration- and time-dependent manner, and can be used for research in the field of neuropathic pain disorders.
    SDUY817
  • HY-121796
    Mixanpril
    		Inhibitor
    Mixanpril is a compound with the ability to modulate insulin sensitivity and has the activity of regulating insulin sensitivity and femoral blood flow in obese Zucker rats. Mixanpril can affect insulin-mediated glucose disposal in obese Zucker rats and also has a regulatory effect on femoral blood flow, with different effects compared to the ACE inhibitor captopril.
    Mixanpril
  • HY-15407S3
    Sacubitril-13C4
    		Inhibitor
    Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19.
    Sacubitril-<sup>13</sup>C<sub>4</sub>
  • HY-114657
    Benproperine
    		Inhibitor
    Benproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.
    Benproperine
  • HY-170961
    SDUY816
    		Inhibitor
    SDUY816 is an oral active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders.
    SDUY816
  • HY-15407BR
    Sacubitril sodium (Standard)
    		Inhibitor
    Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19.
    Sacubitril sodium (Standard)
  • HY-105458
    BL-2401
    		Inhibitor
    BL-2401 is an orally active enkephalinase inhibitor. BL-2401 exhibit antinociceptive and antidepressant-like activitiesin association with endogenous opioid systems. BL-2401 can be used for the research of neurological disease.
    BL-2401
  • HY-N2021AR
    Phosphoramidon Disodium (Standard)
    		Inhibitor
    Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process.
    Phosphoramidon Disodium (Standard)
  • HY-139803
    SCH-39370
    SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
    SCH-39370
  • HY-18209
    Z-13752A
    		Inhibitor
    Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion.
    Z-13752A
Cat. No. Product Name / Synonyms Species Source