Neprilysin
Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10
Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.
Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.
All Product Categories
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Neprilysin Related Products (70)
Related Products (70)
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Recombinant Proteins (2)
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Sacubitril-d4 hemicalcium salt
0 ImagesCat. No.: HY-15407AS1Purity: 98.78%Synonyms: AHU-377-d4 hemicalcium saltSacubitril-d4 hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM.
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Sacubitril (Standard)
0 ImagesSynonyms: AHU-377 (Standard)Sacubitril (Standard) is the analytical standard of Sacubitril. This product is intended for research and analytical applications. Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19.
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PL37
0 ImagesCat. No.: HY-19876CAS No.: 935481-06-4Synonyms: Debio-0827PL37 (Debio-0827) is an orally active, blood-brain barrier permeable dual enkephalinase inhibitor. PL37 inhibits aminopeptidase N, neprilysin, and metalloproteases, thereby blocking the degradation of endogenous enkephalins, elevating enkephalin levels, and activating peripheral μ- and δ-opioid receptors. PL37 induces mitochondrial dysfunction, mitophagy, and apoptosis, inhibits endothelial cell proliferation, migration, invasion, and tube formation, and suppresses hemangioma tumor growth and angiogenesis. PL37 can be used in research related to peripheral neuropathic pain, osteosarcoma-induced hyperalgesia, painful diabetic neuropathy, migraine, bone cancer pain, neuroinflammatory pain, and infantile hemangioma.
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Racecadotril-d5
0 ImagesCat. No.: HY-17399SCAS No.: 1246815-11-1Synonyms: Acetorphan-d5Racecadotril-d5 is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
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AD015
0 ImagesCat. No.: HY-173430CAS No.: 177741-43-4AD015 is a angiotensin-converting enzyme (ACE) and neprilysin (NEP) dual inhibitor. AD015 inhibits NEP, nACE and cACE with IC50s of 0.009, 0.019 and 0.0008 μM, respectively.
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CGS-30440
0 ImagesCat. No.: HY-105319CAS No.: 169319-62-4CGS-30440 is a potent and orally active dual inhibitor of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). CGS-30440 exhibit antihypertensive and natriuretic effects. CGS-30440 also shows protective effect for chronic renal failure. CGS-30440 can be used for the research of cardiovascular disease, such as hypertension.
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Risotilide
0 ImagesCat. No.: HY-116476CAS No.: 120688-08-6Risotilide is an inhibitor of enkephalinase B, which has the ability to inhibit enkephalinase B activity (IC50 value is 0.35 microM), and can also effectively inhibit enkephalinase A (IC50 = 0.02 microM) and aminopeptidase activity (IC50 = 13 microM), and can be regarded as a complete inhibitor of enkephalin biodegradation.
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Thiorphan-d7
0 ImagesCat. No.: HY-W013375SCAS No.: 1276297-68-7Thiorphan-d7 is the deuterium labeled Thiorphan. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM.
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[Des-Tyr1]-Met-Enkephalin
![[Des-Tyr1]-Met-Enkephalin](https://file.medchemexpress.com/product_pic/hy-p2658.gif "Click to View [Des-Tyr1]-Met-Enkephalin Product Detail")
0 ImagesCat. No.: HY-P2658CAS No.: 61370-88-5[Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins.
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Mixanpril
0 ImagesCat. No.: HY-121796CAS No.: 156039-69-9Mixanpril is a compound with the ability to modulate insulin sensitivity and has the activity of regulating insulin sensitivity and femoral blood flow in obese Zucker rats. Mixanpril can affect insulin-mediated glucose disposal in obese Zucker rats and also has a regulatory effect on femoral blood flow, with different effects compared to the ACE inhibitor captopril.
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Sacubitril-13C4
0 ImagesCat. No.: HY-15407S3Synonyms: AHU-377-13C4Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19.
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Benproperine
0 ImagesBenproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.
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SDUY816
0 ImagesCat. No.: HY-170961SDUY816 is an oral active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders.
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Sacubitril sodium (Standard)
0 ImagesSynonyms: AHU-377 sodium (Standard)Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19.
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BL-2401
0 ImagesCat. No.: HY-105458CAS No.: 151774-56-0BL-2401 is an orally active enkephalinase inhibitor. BL-2401 exhibit antinociceptive and antidepressant-like activitiesin association with endogenous opioid systems. BL-2401 can be used for the research of neurological disease.
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Phosphoramidon Disodium (Standard)
0 ImagesCat. No.: HY-N2021ARCAS No.: 164204-38-0Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process.
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SCH-39370
0 ImagesCat. No.: HY-139803CAS No.: 115406-23-0SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
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Z-13752A
0 ImagesCat. No.: HY-18209CAS No.: 193420-09-6Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion.
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SCH-42354
0 ImagesCat. No.: HY-106975CAS No.: 144505-58-8SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity.
