1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Kelatorphan

Kelatorphan 

Cat. No.: HY-10827
Handling Instructions

Kelatorphan is a full inhibitor of enkephalin degrading enzymes.

For research use only. We do not sell to patients.

Kelatorphan Chemical Structure

Kelatorphan Chemical Structure

CAS No. : 92175-57-0

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Kelatorphan is a full inhibitor of enkephalin degrading enzymes.

IC50 & Target

Enkephalin degrading enzyme[1].

In Vivo

The administration of Kelatorphan alone (50 μg) could result in a strong increase of intact [3H]enkephalin content corresponding to 80±11% of total recovered radioactivity[2]. In normal awake rats, Kelatorphan (10±20 mg/kg i.v.) increases minute-volume. The increase in ventilation is due to a dose-dependent increase in breathing frequency. In arthritic rats Kelatorphan (20 mg/kg i.v.) increases ventilation and there is no significant difference between arthritic and non-arthritic rats. In pentobarbital-anesthetized rats, a slight (116%) but significant increase of respiration is also produced by Kelatorphan (20 mg/kg, n=6) 10±15 min after administration. The effects of Kelatorphan are not antagonized by a pretreatment with a small dose of naloxone (0.2 mg/kg i.v., 15 min before Kelatorphan), but a larger dose (1 mg/kg) significantly antagonized Kelatorphan (20 mg/kg) at 5 and 10 min in awake rats[3].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

294.30

Formula

C₁₄H₁₈N₂O₅

CAS No.

92175-57-0

SMILES

O=C(C[[email protected]](C(N[[email protected]@H](C)C(O)=O)=O)CC1=CC=CC=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Kelatorphan
Cat. No.:
HY-10827
Quantity:

Kelatorphan

Cat. No.: HY-10827