1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Kelatorphan


Cat. No.: HY-10827
Handling Instructions

Kelatorphan is a full inhibitor of enkephalin degrading enzymes.

For research use only. We do not sell to patients.

Kelatorphan Chemical Structure

Kelatorphan Chemical Structure

CAS No. : 92175-57-0

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Kelatorphan is a full inhibitor of enkephalin degrading enzymes.

IC50 & Target

Enkephalin degrading enzyme[1].

In Vivo

The administration of Kelatorphan alone (50 μg) could result in a strong increase of intact [3H]enkephalin content corresponding to 80±11% of total recovered radioactivity[2]. In normal awake rats, Kelatorphan (10±20 mg/kg i.v.) increases minute-volume. The increase in ventilation is due to a dose-dependent increase in breathing frequency. In arthritic rats Kelatorphan (20 mg/kg i.v.) increases ventilation and there is no significant difference between arthritic and non-arthritic rats. In pentobarbital-anesthetized rats, a slight (116%) but significant increase of respiration is also produced by Kelatorphan (20 mg/kg, n=6) 10±15 min after administration. The effects of Kelatorphan are not antagonized by a pretreatment with a small dose of naloxone (0.2 mg/kg i.v., 15 min before Kelatorphan), but a larger dose (1 mg/kg) significantly antagonized Kelatorphan (20 mg/kg) at 5 and 10 min in awake rats[3].

Molecular Weight







O=C(C[[email protected]](C(N[[email protected]@H](C)C(O)=O)=O)CC1=CC=CC=C1)NO


Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

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