CGS-30440 

CGS-30440 is a potent and orally active dual inhibitor of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). CGS-30440 exhibit antihypertensive and natriuretic effects. CGS-30440 also shows protective effect for chronic renal failure. CGS-30440 can be used for the research of cardiovascular disease, such as hypertension^[1][2].

CGS-30440 (10-30 mg/kg, p.o.) decreases mean arterial pressure and left ventricular hypertrophy in hypertensive rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

492.63

C₂₅H₃₆N₂O₆S

169319-62-4

COC(C=C1)=CC=C1C[C@@H](C(OCC)=O)NC(C2(CCCC2)NC([C@H](C(C)C)SC(C)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Webb RL, et al. Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1997 Nov;30(5):632-42.  [Content Brief]

  [2]. Cohen DS, et al. Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure. J Cardiovasc Pharmacol. 1998 Jul;32(1):87-95.  [Content Brief]