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  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
製品番号 製品名 CAS 番号 純度 構造式
  • HY-22340
    Azido-PEG4-alcohol 86770-67-4 98.88%
    Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-alcohol
  • HY-138461
    Azido-PEG1 1517-05-1 99.98%
    Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1
  • HY-140214
    Azido-PEG5-amine

    Azido-PEG5-amine

    		516493-93-9 98.0%
    Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-amine
  • HY-107608
    Leukotriene B4

    Leukotriene B4

    		71160-24-2 ≥98.0%
    Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4
  • HY-W008474
    Boc-NH-PEG2-C2-NH2

    Boc-NH-PEG2-C2-NH2

    		153086-78-3 99.38%
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NH2
  • HY-126885
    DBCO-PEG5-NHS ester 2144395-59-3
    DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG5-NHS ester
  • HY-140895
    Biotin-PEG4-amine 663171-32-2 98.0%
    Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-amine
  • HY-W123015
    6-Azidohexanoic acid 79598-53-1 99.20%
    6-Azidohexanoic acid is an ester product.
    6-Azidohexanoic acid
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid

    Fmoc-8-amino-3,6-dioxaoctanoic acid

    		166108-71-0 99.98%
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-8-amino-3,6-dioxaoctanoic acid
  • HY-140755
    Aeide-C1-NHS ester

    Aeide-C1-NHS ester

    		824426-32-6 98.0%
    Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aeide-C1-NHS ester
  • HY-140921
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide 1260247-50-4 98.0%
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
  • HY-130485
    Bromo-PEG2-C2-azide 530151-56-5 98.70%
    Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG2-C2-azide
  • HY-140941
    Biotin-PEG2-C2-iodoacetamide 292843-75-5 98.23%
    Biotin-PEG2-C2-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-C2-iodoacetamide
  • HY-140736
    DSPE-PEG2000-Biotin

    DSPE-PEG-Biotin, MW 2000

    		385437-57-0 99.93%
    DSPE-PEG2000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG2000-Biotin
  • HY-140274
    DBCO-PEG12-NHS ester 2093934-94-0 98.68%
    DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-NHS ester
  • HY-141269
    Methyltetrazine-PEG5-NHS ester 1802907-92-1
    Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG5-NHS ester
  • HY-130653
    Azido-PEG4-C2-acid

    Azido-PEG4-C2-acid

    		1257063-35-6 99.20%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-130184
    Azido-PEG8-NHS ester

    Azido-PEG8-NHS ester

    		1204834-00-3 99.47%
    Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-NHS ester
  • HY-141165
    TCO-NHS ester

    TCO-NHS ester

    		1191901-33-3
    TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-NHS ester
  • HY-140764
    Azido-PEG3-NHS ester 1092654-47-1 ≥98.0%
    Azido-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-NHS ester
PROTAC Linkers Isoform Comparison

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