Vasopressin Receptor
The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V1a, V1b (or V3), and V2. They all belong to the large rhodopsin-like G-protein-coupled receptor family.
The V1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V1a and V1b AVP receptors act through a G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V2 receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.
Vasopressin Receptor Isoform Specific Products
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Vasopressin Receptor Inhibitors
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Vasopressin Receptor Agonists
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Vasopressin Receptor Antagonists
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Vasopressin Receptor Activators
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Vasopressin Receptor Modulator
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Vasopressin Receptor Control
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Vasopressin Receptor Ligand
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Vasopressin Receptor Related Products (126)
Related Products (126)
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Vasopressin Receptor Isoform Comparison
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V1a/V2 antagonist 1
0 ImagesCat. No.: HY-168742V1a/V2 antagonist 1 (Compound 18j) is an orally active dual V1a and V2 receptor antagonist with high binding affinity for both receptors (Ki: 0.13 nM for hV1a, 0.53 nM for hV2 and 0.5 nM for mV1a; IC50: 2.2 nM for hV1a). V1a/V2 antagonist 1 inhibits Oxytocin (HY-17571)-induced scratching behavior in mice.
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JKC 301
0 ImagesCat. No.: HY-P4201CAS No.: 136553-96-3JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking.
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Enuvaptan
0 ImagesCat. No.: HY-139572CAS No.: 2145062-48-0Synonyms: BAY-2327949Enuvaptan (BAY-2327949) is a vasopressin receptor antagonist and has the potential for research into renal and cardiovascular diseases.
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Big Endothelin-1 (1-39), porcine
0 ImagesCat. No.: HY-P2539CAS No.: 120796-99-8Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo.
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Vasopressin Dimer (anti-parallel) TFA
0 ImagesCat. No.: HY-P5214Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.
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Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol
0 ImagesCat. No.: HY-W583271CAS No.: 119700-81-1Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia.
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[Deamino-4-valine, 8-D-arginine]-Vasopressin
![[Deamino-4-valine, 8-D-arginine]-Vasopressin](https://file.medchemexpress.com/product_pic/hy-p4008.gif "Click to View [Deamino-4-valine, 8-D-arginine]-Vasopressin Product Detail")
0 ImagesCat. No.: HY-P4008CAS No.: 43157-23-9Synonyms: dVDAVP[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent possessing protracted effects.
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Niravoline
0 ImagesCat. No.: HY-133173CAS No.: 130610-93-4Synonyms: RU51599Niravoline (RU51599) is an arginine vasopressin (AVP) release inhibitor and a selective kappa opioid receptor agonist. Niravoline has a pure water diuresis effect without associated electrolyte excretion. Niravoline can reduce brain oedema following transient forebrain ischaemia in rats.
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RGH-122
0 ImagesCat. No.: HY-162118CAS No.: 2355304-05-9RGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with Ki value of 0.3 nM and IC50 of 0.9 nM. RGH-122 showes microsomal stability with CLint value of 13/28/25 μL/min/mg.
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[Asu1,6-Arg8]Vasopressin
![[Asu1,6-Arg8]Vasopressin](https://file.medchemexpress.com/product_pic/hy-p4012.gif "Click to View [Asu1,6-Arg8]Vasopressin Product Detail")
0 ImagesCat. No.: HY-P4012CAS No.: 40944-53-4[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture.
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F992
0 ImagesCat. No.: HY-P0041CAS No.: 162277-99-8F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
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Dp[Tyr(methyl)2,Arg8]-Vasopressin
![Dp[Tyr(methyl)2,Arg8]-Vasopressin](https://file.medchemexpress.com/product_pic/hy-p3213.gif "Click to View Dp[Tyr(methyl)2,Arg8]-Vasopressin Product Detail")
0 ImagesCat. No.: HY-P3213CAS No.: 67269-08-3Dp[Tyr(methyl)2,Arg8]-Vasopressin is a non-selective peptide arginine vasopressin Vlb receptor antagonist.
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ASP-7035
0 ImagesCat. No.: HY-186040CAS No.: 790694-26-7ASP-7035 (compound 55) is an arginine vasopressin V2 receptor agonist. ASP-7035 can be used in the research of nocturia.
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2-(3-Trifluoromethylphenyl)glycine hydrochloride
0 ImagesCat. No.: HY-W104304CAS No.: 1134915-25-52-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research.
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Satavaptan
0 ImagesCat. No.: HY-18344CAS No.: 185913-78-4Synonyms: SR 121463Satavaptan (SR 121463) is an antagonist for vasopressin V2 receptor. Satavaptan regulates the vasopressin regulated phosphopeptides and vasopressin-mediated signaling pathway. Satavaptan is potential in ameliorating hyponatremia.
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Conivaptan-d4
0 ImagesCat. No.: HY-129511CAS No.: 1129433-63-1Synonyms: YM 087-d4Conivaptan-d4 (YM 087-d4) is the deuterated-labeled Conivaptan (HY-18347). Conivaptan (YM 087 free base) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan is used for research on hyponatremia and congestive heart failure.
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(D-Arg8)-Inotocin
0 ImagesCat. No.: HY-P5010CAS No.: 745816-74-4(D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R.
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Felypressin (Standard)
0 ImagesFelypressin (Standard) is the analytical standard of Felypressin. This product is intended for research and analytical applications. Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.
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D[LEU4,LYS8]-VP
![D[LEU4,LYS8]-VP](https://file.medchemexpress.com/product_pic/hy-p1163.gif "Click to View D[LEU4,LYS8]-VP Product Detail")
0 ImagesCat. No.: HY-P1163CAS No.: 42061-33-6D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities.
