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Cat. No.: HY-162118

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RGH-122

RGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with K_i value of 0.3 nM and IC₅₀ of 0.9 nM. RGH-122 showes microsomal stability with CL_int value of 13/28/25 μL/min/mg.

For research use only. We do not sell to patients.

CAS No.: 2355304-05-9
Formula: C₂₄H₂₅ClN₄O₃
Molecular Weight:452.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RGH-122 Chemical Structure

CAS No.: 2355304-05-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Vasopressin Receptor Isoforms :

Chemical Information

CAS No. 2355304-05-9
Molecular Weight 452.93
Formula C₂₄H₂₅ClN₄O₃
SMILES

ClC1=CC=[C@]2[N@]3C([C@H](CC4)CC[C@@H]4OC5=NC=CC=C5)=NN=C3CC6(OCCO6)CC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baska F, et al. Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist. J Med Chem. 2024 Jan 11;67(1):643-673. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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RGH-122

All Vasopressin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RGH-122 Related Classifications

HY-162118 Related Classifications