[Deamino-4-valine, 8-D-arginine]-Vasopressin
[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent possessing protracted effects.
For research use only. We do not sell to patients.
- CAS No.: 43157-23-9
- Formula: C46H65N13O11S2
- Molecular Weight:1040.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Deamino-4-valine, 8-D-arginine]-Vasopressin Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p4008.gif "Click to View [Deamino-4-valine, 8-D-arginine]-Vasopressin Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Vasopressin Receptor Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.05 nM
Compound: 2; [Val4]dDAVP
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Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay
Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay
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[PMID: 31022340] |
| HEK293 | EC50 |
24 nM
Compound: 2; [Val4]dDAVP
|
Agonist activity at recombinant human V1B receptor expressed in HEK293 cells measured after 5 hrs by luciferase reporter gene assay
Agonist activity at recombinant human V1B receptor expressed in HEK293 cells measured after 5 hrs by luciferase reporter gene assay
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[PMID: 31022340] |
Chemical Information
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CAS No. 43157-23-9
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Molecular Weight 1040.22
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Formula C46H65N13O11S2
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Synonyms
dVDAVP
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Sequence
{Mpa}-Tyr-Phe-Val-Asn-Cys-Pro-{dArg}-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)
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Sequence Shortening
{Mpa}-YFVNCP-{dArg}-G-NH2 (Disulfide bridge:Mpa1-Cys6)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
References
[1]. M Manning, et al. [1-deaminopenicillamine,4-valine]-8-D-arginine-vasopressin, a highly potent inhibitor of the vasopressor response to arginine-vasopressin. J Med Chem. 1977 Sep;20(9):1228-30. [Content Brief]
[2]. M Manning, et al. Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects. J Med Chem. 1973 Sep;16(9):975-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[Deamino-4-valine, 8-D-arginine]-Vasopressin Related Classifications
HY-P4008 Related Classifications
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