2. Signaling Pathways
  3. Stem Cell/Wnt
  4. BMI1

BMI1

Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1

B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a component of the polycomb repressive complex 1 (PRC1), is recognized as a polycomb protein that prevents premature senescence and maintains the self-renewal capacity of stem cells.

BMI1 Related Products (11):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15888
    PTC-209
    		Inhibitor 99.76%
    PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment.
    PTC-209
  • HY-112041
    Unesbulin
    		Inhibitor 99.17%
    Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity.
    Unesbulin
  • HY-160924
    MS147
    		Degrader 98.31%
    MS147 is a VHL-based PROTAC degrader of BMI1 and RING1B (polycomb repressive complex 1 core components). MS147 directly binds EED and VHL E3 ligase, recruiting the ligase to the EED-BMI1/RING1B complex to induce time-dependent, ubiquitination-mediated degradation of BMI1 and RING1B. MS147 reduces histone H2A Lys119 mono-ubiquitination without altering histone H3 Lys27 tri-methylation and inhibits cancer cells proliferation. MS147 can be used for the research of cancer, such as chronic myelogenous leukemia and b-cell lymphoma. (Pink: BMI1/RING1B ligand (HY-183634); Blue: VHL ligand (HY-125845); Black: linker)
    MS147
  • HY-15888A
    PTC-209 hydrobromide
    		Inhibitor 99.02%
    PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment.
    PTC-209 hydrobromide
  • HY-103696
    PTC-028
    		Inhibitor 98.0%
    PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis.
    PTC-028
  • HY-143658
    SH498
    		Inhibitor
    SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.
    SH498
  • HY-172617
    APD-94
    		Inhibitor
    APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study.
    APD-94
  • HY-143655
    QW24
    		Inhibitor
    QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research.
    QW24
  • HY-N0992
    1,6,7-Trihydroxyxanthone
    		Inhibitor
    1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16.
    1,6,7-Trihydroxyxanthone
  • HY-103696R
    PTC-028 (Standard)
    		Inhibitor
    PTC-028 (Standard) is the analytical standard of PTC-028 (HY-103696). This product is intended for research and analytical applications. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis.
    PTC-028 (Standard)
  • HY-183634
    BMI1/RING1B ligand-1
    BMI1/RING1B ligand-1 is a BMI1/RING1B ligand. BMI1/RING1B ligand-1 can be used to synthesize PROTAC S147 (HY-160924).
    BMI1/RING1B ligand-1