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PTC-209 hydrobromide 

Cat. No.: HY-15888A
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PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment.

For research use only. We do not sell to patients.

PTC-209 hydrobromide Chemical Structure

PTC-209 hydrobromide Chemical Structure

CAS No. : 1217022-63-3

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Top Publications Citing Use of Products

    PTC-209 hydrobromide purchased from MCE. Usage Cited in: Cell Stem Cell. 2017 May 4;20(5):621-634.e6.

    The Combination Therapy of Cisplatin Plus PTC-209 Potently Eradicates Bmi1+ CSCs and Inhibits Tumor Progression by Lineage Tracing. Western blots show that Bmi1 is reduced in tumors treated with PTC-209.

    PTC-209 hydrobromide purchased from MCE. Usage Cited in: Nat Commun. 2018 Feb 5;9(1):500.

    BMI1-specific antagonist inhibits androgen receptor (AR)-signaling pathway. C4-2 (a) or 22Rv1 (b) is treated with PTC209 in indicated concentration for 48 h, BMI1 and AR are tested by western blot, and GAPDH served as loading control.

    PTC-209 hydrobromide purchased from MCE. Usage Cited in: Oncogene. 2020 Jan;39(1):17-29.

    BMI1 inhibitor delays CRPC progression in vivo. C4-2 cells are treated with PTC209.
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    Description

    PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2].

    IC50 & Target

    IC50: 0.5 μM (BMI-1, in HT1080 tumor cells)[1]

    In Vitro

    PTC-209 (0.01-10 µM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested[2].
    PTC-209 (1-2.5 μM) inhibits STAT3 phosphorylation in A549 lung cancer cells and MDA-MB-231 breast cancer cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: Lung (LNM35, A549 cells), breast (MDA-MB-231 and T47D cells), and colon (HT-29, HCT-116, and HCT8/S11 cells)
    Concentration: 0.01-10 µM
    Incubation Time: 24, 48, and 72 hour
    Result: Induced a concentration- and time-dependent decrease in the cellular viability of all cell lines tested.
    In Vivo

    PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nude mice (male, aged 8-10 weeks, HCT1116 cell-derived tumor)[1]
    Dosage: 60 mg/kg body weight
    Administration: Subcutaneously; once a day for 11 days
    Result: Significantly reduced tumor volume.
    Molecular Weight

    576.10

    Formula

    C₁₇H₁₄Br₃N₅OS

    CAS No.
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    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    PTC-209 hydrobromide
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