Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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(1R)-LSN3160440
0 ImagesCat. No.: HY-153193APurity: 98.43%(1R)-LSN3160440 is the (1R) chiral isomer of LSN3160440 (HY-153193). LSN3160440 is an allosteric modulator of GLP-1R.
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(rac)-Valategrast
0 ImagesCat. No.: HY-14190ACAS No.: 2935063-80-0Synonyms: (rac)-R-411 free base(rac)-Valategrast ((rac)-R-411 free base) is a racemic compound of Valategrast (HY-14190). Valategrast is a potent, orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7. Valategrast may be used in research on chronic obstructive pulmonary disease (COPD) and asthma.
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3,4-Methylenedioxypropiophenone
0 ImagesCat. No.: HY-W016621CAS No.: 28281-49-43,4-Methylenedioxypropiophenone (Compound 4) is an isomer of 3,4-methylenedioxyphenyl-2-propanone. 3,4-Methylenedioxypropiophenone has potent activity against leishmania.
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Rac-Sphingosylphosphorylcholine
0 ImagesRac-Sphingosylphosphorylcholine is a racemate of Sphingosylphosphorylcholine (HY-132187).
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(Rac)-3′-Hydroxy simvastatin
0 ImagesCat. No.: HY-136345CAS No.: 126313-98-2(Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research.
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(3S,5R)-Pitavastatin calcium
0 Images(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin Calcium (HY-B0144). Pitavastatin is a potent HMG-CoA reductase inhibitor.
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(E/Z)-Acetamiprid
0 ImagesCat. No.: HY-B0823ACAS No.: 160430-64-8(E/Z)-Acetamiprid is the E/Z mixture of Acetamiprid (HY-B0823). Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.
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6-epi Doxycycline
0 Images6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations.
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(R)-PAD-PF2
0 ImagesCat. No.: HY-176710APurity: 99.95%(R)-PAD-PF2 is an isomer of PAD-PF2 (HY-176710). PAD-PF2 is a PAD family inhibitor, as well as a κ-opioid receptor agonist (EC50 = 7.55 μM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 μM).
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trans-Glutaconic acid
0 ImagesSynonyms: trans-2-Pentenedioic acidtrans-Glutaconic acid (trans-2-Pentenedioic acid) is the trans isomer of Glutaconic acid (HY-W073501A). trans-Glutaconic acid is a neurotoxic metabolite. trans-Glutaconic acid induces weak neurotoxicity in cultured cerebral neocortical neurons. trans-Glutaconic acid elicits significant electrophysiological responses in rat neocortical wedge preparations at high concentrations. trans-Glutaconic acid can be used in studies related to glutaric acidemia type 1.
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(1R,3R)-RSL3 (Standard)
0 ImagesCat. No.: HY-100218CRCAS No.: 1219810-15-7(1R,3R)-RSL3 (Standard) is the analytical standard of (1R,3R)-RSL3 (HY-100218C). This product is intended for research and analytical applications. (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.
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(R)-Zevaquenabant
0 ImagesCat. No.: HY-141411BPurity: 99.15%Synonyms: (R)-MRI-1867(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant (HY-141411A). Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD).
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(-)-Talinolol
0 ImagesSynonyms: (-)-Cordanum(-)-Talinolol ((-)-Cordanum) is the S-configuration levorotatory single optical enantiomer of the racemic mixture of Talinolol (HY-108286). Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol possesses cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used substrate for P-glycoprotein (P-gp) active probes.
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D-Lysine-d8 dihydrochloride
0 ImagesCat. No.: HY-W035399SD-Lysine-d8 dihydrochloride is the d8-labeled D-Lysine (HY-Y1091). D-Lysine is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine can be used in research related to cancer and diabetes.
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8-Amino-7-oxononanoic acid hydrochloride
0 ImagesCat. No.: HY-172009CAS No.: 21286-96-48-Amino-7-oxononanoic acid hydrochloride is a racemic mixture of 8(R)-KAPA and the vitamer of biotin 8(S)-KAPA.
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(±)-Scopolamine
0 Images(±)-Scopolamine (Atroscine) is the racemic form of Scopolamine (HY-N0296) and belongs to the tropane alkaloids. (±)-Scopolamine can be synthesized as the free base via an H2O2-mediated epoxidation reaction using 6,7-dehydrotropine as a key intermediate. (±)-Scopolamine is useful for the synthesis of tropane alkaloids and stereochemical studies.
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(S)-(-)-Propranolol
0 Images(S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain.
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(S)-Purvalanol B
0 ImagesSynonyms: (S)-NG 95(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.
