2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Others
  3. P-glycoprotein Cytochrome P450 Drug Isomer
  4. NSC 23925B

NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers.

For research use only. We do not sell to patients.

NSC 23925B

NSC 23925B Chemical Structure

CAS No. : 1369591-04-7

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NSC 23925B Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers[1].

In Vitro

NSC 23925B potently reverses Pgp-mediated multidrug resistance (MDR) in multidrug-resistant human breast cancer and colon cancer cell lines[1].
NSC 23925B inhibits Pgp-mediated chemoresistance in ovarian cancer cells and osteosarcoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 23925B Related Antibodies
In Vivo

NSC 23925B (2.50-93.75 mg/kg; i.p.; i.v.; single dose) exhibits favorable pharmacokinetic profiles with high bioavailability, measurable plasma concentrations over 24 hours, and limited toxicity in male BALB/c mice, with a maximum tolerated dose of at least 68.80 mg/kg (i.p.) in males and 24.70 mg/kg (i.v.) in both sexes[1].
NSC 23925B (2.50-47.20 mg/kg; i.p.; i.v.; single dose) exhibits favorable pharmacokinetic profiles with high bioavailability, measurable plasma concentrations over 24 hours, and limited toxicity in male Sprague-Dawley rats, with a maximum tolerated dose of at least 33.10 mg/kg (i.p.) and 38.80 mg/kg (i.v.) in males[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

421.36

Formula

C22H26Cl2N2O2
CAS No.
SMILES

O[C@H]([C@@]1([H])CCCCN1)C2=CC(C3=CC=C(C=C3)OC)=NC4=C2C=CC=C4.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC 23925B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 23925B1369591-04-7P-glycoproteinCytochrome P450Drug IsomerP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsCYP2B6CYP3A4CYP1A2Sprague-Dawley ratscancer cellsCYP2D6multidrug resistanceBALB/c micecytochrome P450Inhibitorinhibitorinhibit

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HY-117593
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