2. Signaling Pathways
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  4. Fluorescent Dye

Fluorescent Dye

Fluorescence is a phenomenon of photoluminescence in luminescence. When an atom is irradiated by light, some electrons around the nucleus jump from their original orbitals to higher energy orbitals under the influence of light energy, i.e., from the ground state to the first or second excited single-line state, etc. Due to the instability of the first or second excited singlet state, the electron returns from the excited singlet state to the ground state accompanied by released energy, resulting in fluorescence.

Fluorescent dyes can be covalently bound or physically adsorbed in the structure of the substance. The fluorescence properties allow for the characterization, localization and quantitative analysis of the labeled object. Fluorescent dyes have shown great potential for the detection of proteins, nucleic acids, cells, and immunoassays, attributed to the advantages in non-radioactive contamination, simple experimental operation and easy observation.

Fluorescent dyes have penetrated many fields such as pharmacology, physiology, environmental science, and information science, as well as functional studies of proteins and drug screening.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-177616D
    Cy3 labled Archexin sodium
    Cy3 labled Archexin sodium is a Cy3 labled Archexin sodium.
    Cy3 labled Archexin sodium
  • HY-D3187
    HMRef-αMan
    HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma.
    HMRef-αMan
  • HY-D1967
    ATTO 633 azide
    ATTO 633 Azide is an azide derivative of ATTO 520 with excitation/emission maxima at 630/651 nm.
    ATTO 633 azide
  • HY-P3110
    Ac-DNLD-AMC
    Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.
    Ac-DNLD-AMC
  • HY-P3392D
    FAM labled Zilganersen sodium
    FAM labled Zilganersen sodiumis a FAM labled Zilganersen sodium.
    FAM labled Zilganersen sodium
  • HY-149835
    TTX-P
    TTX-P is a fluorescent probe. TTX-P responds in situ to the overexpressed alkaline phosphatase (ALP) in liver, imaging of diabetic liver injury in the near-infrared second-window (NIR-II) region.
    TTX-P
  • HY-169799
    Cholylglycylamidofluorescein
    Cholylglycylamidofluorescein (CGamF) is a fluorescent probe for hepatic bile acid transport. Cholylglycylamidofluorescein is composed of Cholic acid conjugated via a glycylamino linkage to fluorescein. (Ex/Em = 492/515 nM in Aqueous)
    Cholylglycylamidofluorescein
  • HY-167255
    JC-10
    JC-10 is a lipophilic mitochondrial membrane potential indicator and is a fluorescent dye. JC-10 accumulates and aggregates in healthy mitochondria to emit red fluorescence; exists as a monomer emitting green fluorescence in the cytosol or apoptotic cells with collapsed mitochondrial membrane potential, enabling measurement of mitochondrial depolarization via the green/red fluorescence ratio.
    JC-10
  • HY-103467
    NPE-caged-HPTS sodium
    NPE-caged-HPTS sodium is a caged fluorophore that fluoresces upon uncaged fluorophore release, releasing the free highly polar fluorophore HPTS (Exc=470/40 nm, Em=525/50 nm). HPTS releases the fluorophore rapidly and uniformly, allowing for measurement of diffusion within tissues, with a diffusion coefficient of μm2s-1, similar to that of synaptic L-glutamate.
    NPE-caged-HPTS sodium
  • HY-D1905
    ICG acid
    ICG acid is a fluorescent dye used in medical diagnostics. ICG acid has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue. ICG acid has been used in fluorescence-guided surgery to identify critical structures, including intra-abdominal tumors.
    ICG acid
  • HY-D2882D
    RB-PEG3400-OH
    RB-PEG3400-OH (Rhodamine B-PEG3400-OH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a Hydroxyl group. RB-PEG3400-OH can be used for fluorescent labeling and imaging (Ex/Em=546/610 nm).
    RB-PEG3400-OH
  • HY-112980E
    Cy3 labled Nusinersen sodium
    Cy3 labled Nusinersen sodium is a Cy3 labled Nusinersen sodium.
    Cy3 labled Nusinersen sodium
  • HY-W009472
    L-Pyroglutamic acid β-naphthylamide
    L-Pyroglutamic acid β-naphthylamide (PYR) is aglutamic acid derivatives.
    L-Pyroglutamic acid β-naphthylamide
  • HY-D2887D
    RB-PEG3400-DSPE
    RB-PEG3400-DSPE (Rhodamine B-PEG3400-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG3400-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm).
    RB-PEG3400-DSPE
  • HY-D1897
    6-TET phosphoramidite
    6-TET phosphoramidite (5′-Tetrachlorofluorescein phosphoramidite) is a fluorescent dye that can be used for labeling an oligonucleotide with fluorescein.
    6-TET phosphoramidite
  • HY-W197393
    3,6-Diaminoacridine sulfate
    Proflavine sulfate is a multifunctional acridine compound. 3,6-Diaminoacridine sulfate is an acridine dye and also a DNA inserter. Proflavine sulfate is a potent broad-spectrum antibacterial agent, and its mechanism is to insert into bacterial DNA, interfering with replication and transcription, causing bacterial lysis. 3,6-Diaminoacridine sulfate is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine sulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus and long-term exposure may induce skin cancer or other malignant tumors.
    3,6-Diaminoacridine sulfate
  • HY-D2842D
    FITC-PEG5000-biotin
    FITC-PEG5000-biotin is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). FITC-PEG5000-biotin can be used for fluorescent labeling and imaging.
    FITC-PEG5000-biotin
  • HY-DY1072
    ICG NHS ester (solution)
    ICG NHS ester (ICG-OSu) (solution) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes.
    Solvent and concentration: DMSO: 10 mM
    ICG NHS ester (solution)
  • HY-400541
    NBD dodecanoic acid N-succinimidyl ester
    NBD dodecanoic acid N-succinimidyl ester is a fluorescent dye.
    NBD dodecanoic acid N-succinimidyl ester
  • HY-D2111
    TAMRA-PEG2-N3
    TAMRA-PEG2-N3 is a TAMRA (HY-135640) dye derivative containing 4 PEG units. TAMRA-PEG2-N3 undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkynyl group (N3). It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    TAMRA-PEG2-N3
Cat. No. Product Name / Synonyms Application Reactivity