TTX-P 

TTX-P is a fluorescent probe. TTX-P responds in situ to the overexpressed alkaline phosphatase (ALP) in liver, imaging of diabetic liver injury in the near-infrared second-window (NIR-II) region^[1].

TTX-P (10 μM) is responsive to alkaline phosphatase (ALP) and correspondingly emits NIR-II fluorescent signals which are suitable for imaging (at 920 nm)^[1].
TTX-P (10 μM; HepG2, 4T1, and LO2 cells) can detect and monitor the activity of ALP in cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TTX-P (5 mg/kg; Intratumoral injection; BALB/C nude mice with 4T1 cells xenografts) has the ability to detect and monitor the activity of endogenous ALP in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

786.83

C₄₆H₃₅N₄O₅PS

CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C3=N/C(S/C3=C\C4=C5OC6=C(C=C5CCC4)C=CC(C7=CC=C(C=C7)OP(O)(O)=O)=C6)=C(C#N)/C#N)C8=CC=C(C=C8)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zi KC, et, al. Visualizing Detection of Diabetic Liver Injury by a Biomarker-Activatable Probe via NIR-II Fluorescence Imaging. Chem. Biomed. Imaging 2023.