2. Signaling Pathways
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Related Products (10678):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1234S
    Octinoxate-13C,d3
    Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
    Octinoxate-<sup>13</sup>C,d<sub>3</sub>
  • HY-W725480
    Carfentrazon-ethyl-d5
    Carfentrazon-ethyl-d5 is the deuterium labeled Carfentrazon-ethyl-d5 (HY-W725480).
    Carfentrazon-ethyl-d<sub>5</sub>
  • HY-107405S
    TC-N 1752-d5
    TC-N 1752-d5 is deuterium-labeled TC-N 1752 (HY-107405).
    TC-N 1752-d<sub>5</sub>
  • HY-132466S
    Hydroxy Torsemide-d7
    Hydroxy Torsemide-d7 is the deuterium labeled Hydroxy Torsemide.
    Hydroxy Torsemide-d<sub>7</sub>
  • HY-10405S
    Pamapimod-d4
    Pamapimod-d4 (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.
    Pamapimod-d<sub>4</sub>
  • HY-B0071S2
    Granisetron-d6 (Standard)
    Granisetron-d6 (BRL 43694-d6) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
    Granisetron-d<sub>6</sub> (Standard)
  • HY-14538S2
    Haloperidol-d4 N-Oxide
    Haloperidol-d4 N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
    Haloperidol-d<sub>4</sub> N-Oxide
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-<sup>15</sup>N<sub>5</sub>
  • HY-B1252AS
    Cefalonium-d4 hydrate
    Cefalonium-d4 (hydrate) is the deuterium labeled Cefalonium (hydrate)(HY-B1252A).Cefalonium hydrate is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci.
    Cefalonium-d<sub>4</sub> hydrate
  • HY-W777138
    rel-(1S,2R)-Dihydro bupropion-d9
    rel-(1S,2R)-Dihydro bupropion-d9 is the deuterium labeled rel-(1S,2R)-Dihydro bupropion (HY-178240). rel-(1S,2R)-Dihydro bupropion is a metabolite of bupropion. rel-(1S,2R)-Dihydro bupropion can promote endogenous IL-10 production and inhibit Th1 cytokines (IL-12 and TNF-α). rel-(1S,2R)-Dihydro bupropion can induce immune response transition from Th1 to Th2. rel-(1S,2R)-Dihydro bupropion can be used for research on inflammatory conditions.
    rel-(1S,2R)-Dihydro bupropion-d<sub>9</sub>
  • HY-132437S
    6-Hydroxy Bentazon-d7
    6-Hydroxy Bentazon-d7 is the deuterium labeled 6-Hydroxy Bentazon.
    6-Hydroxy Bentazon-d<sub>7</sub>
  • HY-166341S
    S 8849-1-d4 free base
    S 8849-1-d4 (free base) (Tianeptine metabolite MC5-d4) is deuterium labeled S 8849-1 (free base). S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants.
    S 8849-1-d<sub>4</sub> free base
  • HY-123672S
    Lovastatin-d3 hydroxy acid sodium
    Lovastatin-d3 hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
    Lovastatin-d<sub>3</sub> hydroxy acid sodium
  • HY-121605S
    RL71-d6
    RL71-d6 is a deuterium labeled RL71 (HY-121605). RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks.
    RL71-d<sub>6</sub>
  • HY-B0331S1
    Enalapril-d3
    Enalapril-d3 (MK-421-d3) is deuterium labeled Enalapril. Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research.
    Enalapril-d<sub>3</sub>
  • HY-B1184S
    Mephenytoin-d3
    (Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.
    Mephenytoin-d<sub>3</sub>
  • HY-W588263S1
    Indole-3-acetyl glutamate-d4
    Indole-3-acetyl glutamate-d4 (IAGlu-d4) is deuterium labeled Indole-3-acetyl glutamate. Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants.
    Indole-3-acetyl glutamate-d<sub>4</sub>
  • HY-W777418
    Isosorbide mononitrate-13C6
    Isosorbide mononitrate-13C6 (Isosorbide-5-mononitrate-13C6) is 13C-labeled Isosorbide mononitrate (HY-B0642).
    Isosorbide mononitrate-<sup>13</sup>C<sub>6</sub>
  • HY-W662572S
    Pyroxsulam-d6
    Pyroxsulam-d6 (N-(5,7-Dimethoxy-d6[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide.
    Pyroxsulam-d<sub>6</sub>
  • HY-B1137S
    Ramifenazone-d7
    Ramifenazone-d7 is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities.
    Ramifenazone-d<sub>7</sub>