Vibunazole
Based on 1 Customer Validation
Vibunazole (BAY-N-7133) is an antifungal azole agent. Vibunazole inhibits coccidioidostatic.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 80456-55-9
- Formula: C15H20ClN3O2
- Molecular Weight:309.79
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Antifungal Compound Library
HY-L048
-
Human Metabolite Library
HY-L123
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
Biological Activity
Vibunazole shows the coccidioidostatic but not coccidioidicidal effect on strain Silveira in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female Swiss-Webster albino mice (26-30 g) were injected intratracheally with arthroconidia of Coccidioides imrnitis[1].
-
Dosage:0, 2.5, 5 or 10 mg/kg
-
Administration:i.v.; once a day; for 30 days
-
Result:The dose of 2.5 mg/kg body wt/injection resulted in a significant decrease in mortality.
The 5 and 10 mg/kg doses yielded serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 μg/mL and 1.5 μg/mL, respectively) for periods in excess of 30 min after injection.
Chemical Information
-
CAS No. 80456-55-9
-
Appearance Solid
-
Molecular Weight 309.79
-
Formula C15H20ClN3O2
-
Color White to off-white
-
SMILES
OC(C(C)(C)C)(COC1=CC=C(Cl)C=C1)CN2N=CN=C2
-
Synonyms
BAY-N-7133
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (322.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2280 mL | 16.1400 mL | 32.2799 mL | 80.6998 mL |
| 5 mM | 0.6456 mL | 3.2280 mL | 6.4560 mL | 16.1400 mL | |
| 10 mM | 0.3228 mL | 1.6140 mL | 3.2280 mL | 8.0700 mL | |
| 15 mM | 0.2152 mL | 1.0760 mL | 2.1520 mL | 5.3800 mL | |
| 20 mM | 0.1614 mL | 0.8070 mL | 1.6140 mL | 4.0350 mL | |
| 25 mM | 0.1291 mL | 0.6456 mL | 1.2912 mL | 3.2280 mL | |
| 30 mM | 0.1076 mL | 0.5380 mL | 1.0760 mL | 2.6900 mL | |
| 40 mM | 0.0807 mL | 0.4035 mL | 0.8070 mL | 2.0175 mL | |
| 50 mM | 0.0646 mL | 0.3228 mL | 0.6456 mL | 1.6140 mL | |
| 60 mM | 0.0538 mL | 0.2690 mL | 0.5380 mL | 1.3450 mL | |
| 80 mM | 0.0403 mL | 0.2017 mL | 0.4035 mL | 1.0087 mL | |
| 100 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8070 mL |
Vibunazole Related Classifications
HY-100121 Related Classifications
Powered by Bioz