1. Anti-infection
  2. Fungal

Vibunazole (Synonyms: BAY-N-7133)

Cat. No.: HY-100121
Handling Instructions

Vibunazole is a new antifungal azole.

For research use only. We do not sell to patients.

Vibunazole Chemical Structure

Vibunazole Chemical Structure

CAS No. : 80456-55-9

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10 mg USD 240 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Vibunazole is a new antifungal azole.

In Vitro

Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1].

In Vivo

The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1].

Animal Administration

Under pentobarbital anesthesia 26 to 30 g female Swiss-Webster albino mice are injected intratracheally with either 0.05 mL sterile 0.9 % NaCI solution or 150 arthroconidia of Coccidioides imrnitis (strain Silveira) suspended in 0.05 mL of 0.9 % NaCI solution. Treatment of cohorts of ten infected and ten uninfected mice is begun 72 h after inoculation. Daily i.v. injections (tail vein) of 0.1 mL of 5 % glucose solution delivering either 0, 2.5, 5 or 10 mg/kg/dose of Vibunazole are given for 30 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-100121