2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. A-349821

A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. In rats, [3H]-A-349821 penetrated the brain, showing higher levels in the cortex compared to the cerebellum, indicating selective H3 receptor binding. Its cortical occupancy was saturable, correlating with in vitro binding data. Inhibition studies with ABT-239 and other H3 antagonists showed dose-dependent reductions in receptor occupancy, matching blood levels associated with cognitive efficacy in preclinical models. [3H]-A-349821 thus serves as a valid tracer for H3 receptor occupancy, aiding in the development and clinical interpretation of H3 receptor antagonists.

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A-349821

A-349821 Estructura química

No. CAS : 556835-30-4

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A-349821 Related Antibodies

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Descripciòn

A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. In rats, [3H]-A-349821 penetrated the brain, showing higher levels in the cortex compared to the cerebellum, indicating selective H3 receptor binding. Its cortical occupancy was saturable, correlating with in vitro binding data. Inhibition studies with ABT-239 and other H3 antagonists showed dose-dependent reductions in receptor occupancy, matching blood levels associated with cognitive efficacy in preclinical models. [3H]-A-349821 thus serves as a valid tracer for H3 receptor occupancy, aiding in the development and clinical interpretation of H3 receptor antagonists[1].

Peso molecular

536.58

Fòrmula

C28H35F3N2O5
No. CAS
SMILES

FC(F)(C(O)=O)F.C[C@H](CC[C@H]1C)N1CCCOC2=CC=C(C3=CC=C(C(N4CCOCC4)=O)C=C3)C=C2
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A-349821 Related Classifications

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Keywords:

A-349821556835-30-4A349821A 349821Histamine ReceptorInhibitorinhibitorinhibit

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Nombre del producto:
A-349821
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HY-12193
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